(Q71726924)

English

Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma

scientific article published on 01 September 1996

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference

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author name string

R R Dickason

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

J D English

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

D P Huston

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

publication date

1 September 1996

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Journal of Molecular Medicine

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

74

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

535-546

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopics asthmatics, and atopic and nonatopic controls

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced detection of human IL-5 in biological fluids utilizing murine monoclonal antibodies which delineate distinct neutralizing epitopes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of recombinant human interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody to interleukin-5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory effect of cytokines on eosinophil degranulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creation of a biologically active interleukin-5 monomer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and functions of interleukin-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of human basophil histamine release by interleukin 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial purification and characterization of a BCGFII from EL4 culture supernatants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 inhibits HIV-1 replication and is induced by tat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-5 induces tumor suppression by peritoneal exudate cells in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-tumor effects of interleukin-4 and interleukin-5 against mouse B cell lymphoma and possible mechanisms of their action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of interleukin-10 receptors on human and mouse cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineation of IL-5 domains predicted to engage the IL-5 receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of human mast cells based on cytokine content

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human interleukin 5 is a selective activator of human eosinophil function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-5 activates a 45-kilodalton mitogen-activated protein (MAP) kinase and Jak-2 tyrosine kinase in human eosinophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutated interleukin-5 monomers are biologically inactive

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural comparisons among the short-chain helical cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-5 is the predominant eosinophilopoietin produced by cloned T lymphocytes in hypereosinophilic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of an antibody to interleukin-5 in a monkey model of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of the kinetics of binding and internalization of IL-5 in murine IL-5 receptors of high and low affinity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometry of interaction between interferon gamma and its receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8892059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00204980

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8892059%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

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