(Q71730057)

English

Interspecies differences in the kinetic properties of deoxycytidine kinase elucidate the poor utility of a phase I pharmacologically directed dose-escalation concept for 2-chloro-2'-deoxyadenosine

scientific article published on 01 January 1995

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Interspecies differences in the kinetic properties of deoxycytidine kinase elucidate the poor utility of a phase I pharmacologically directed dose-escalation concept for 2-chloro-2'-deoxyadenosine (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

author name string

V Reichelová

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

G Juliusson

2

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

T Spasokoukotskaja

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

S Eriksson

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

J Liliemark

5

1 reference

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20 October 2019

publication date

1 January 1995

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20 October 2019

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

36

1 reference

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20 October 2019

6

1 reference

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20 October 2019

524-529

1 reference

Europe PubMed Central

PubMed publication ID

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20 October 2019

https://scigraph.springernature.com/pub.10.1007/bf00685803

0 references

2 cloning and expression of mouse deoxycytidine kinase. Pure recombinant mouse and human enzymes show differences in substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

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2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

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The impact of pharmacokinetically guided dose escalation strategies in phase I clinical trials: critical evaluation and recommendations for future studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein binding of 2-chloro 2'-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

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Pharmacology and Clinical Toxicity of 4'-Iodo-4'-deoxydoxorubicin: An Example of Successful Application of Pharmacokinetics to Dose Escalation in Phase I Trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of 2-chloro-2'-deoxyadenosine in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential roles for preclinical pharmacology in phase I clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclopentenyl cytosine: interspecies predictions based on rodent plasma and urine kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacokinetics and toxicity of the anthrapyrazole anti-cancer drug CI-941 in the mouse: a guide for rational dose escalation in patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid, and T-lymphocytic colony growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologically guided phase I clinical trials based upon preclinical drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetically guided dose escalation in phase I clinical trials. Commentary and proposed guidelines. EORTC Pharmacokinetics and Metabolism Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New chemotherapeutic agent: 2-chlorodeoxyadenosine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

43 Deoxycytidine kinase from calf thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative pharmacokinetics of cisplatin and three analogues in mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/7554045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00685803

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7554045%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

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