(Q72208047)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

title

Analysis of antibody-enzyme conjugate clearance by investigation of prodrug and active drug in an ADEPT clinical study (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

author name string

Springer CJ

1

1 reference

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24 October 2019

Poon GK

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Sharma SK

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Bagshawe KD

4

1 reference

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24 October 2019

publication date

1 January 1994

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24 October 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

volume

24-25

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24 October 2019

page(s)

193-207

1 reference

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Identification of prodrug, active drug, and metabolites in an ADEPT clinical study

24 October 2019

cites work

1 reference

12 December 2020

Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model

1 reference

12 December 2020

Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation

1 reference

12 December 2020

Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method

1 reference

12 December 2020

Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide

1 reference

12 December 2020

A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

1 reference

12 December 2020

Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate

1 reference

12 December 2020

Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

1 reference

12 December 2020

Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy

1 reference

12 December 2020

Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice

1 reference

12 December 2020

A cytotoxic agent can be generated selectively at cancer sites

1 reference

12 December 2020

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure

1 reference

12 December 2020

Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)

1 reference

12 December 2020

Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate

1 reference

12 December 2020

Antibody directed enzymes revive anti-cancer prodrugs concept

1 reference

12 December 2020

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages

1 reference

12 December 2020

Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02789230

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7736524%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

1 reference