(Q72338610)

English

The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes

scientific article published on 01 September 1993

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

author name string

J L Buss

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

B B Hasinoff

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

publication date

1 September 1993

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

Agents and Actions

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

40

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Europe PubMed Central

PubMed publication ID

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26 October 2019

1-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

86-95

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

The hydrolysis activation of the doxorubicin cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk factors for doxorubicin-induced congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis for anthracycline antibiotic stimulation of oxygen consumption by HL-60 cells and mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardioxane--ICRF-187 towards anticancer drug specificity through selective toxicity reduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187) by liquid chromatographic and mass spectral analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamics of the hydrolysis-activation of the cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metal binding by pharmaceuticals. Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumour agent ICRF 159 and its inactive homologue ICRF 192

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro evidence for direct complexation of ADR-529/ICRF-187 [(+)-1,2-bis-(3,5-dioxo-piperazin-1-yl)propane] onto an existing ferric-anthracycline complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

dl-N,N'-dicarboxamidomethyl-N,N'-dicarboxymethyl-1,2-diaminopropane (ICRF-198) and d-1,2-bis(3,5-dioxopiperazine-1-yl)propane (ICRF-187) inhibition of Fe3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adria

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of the cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yL)propane); its hydrolysis product (ICRF-198); and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enzymatic hydrolysis-activation of the adriamycin cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin and its iron(III) and copper(II) complexes. Glutathione-induced dissociation; cytochrome c oxidase inactivation and protection; binding to cardiolipin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effectiveness of (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxyradical production results from the Fe3(+)-doxorubicin complex undergoing self-reduction by its alpha-ketol group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment with ICRF-187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/8147274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01976756

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8147274%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

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