(Q72519987)

English

A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine

scientific article published on 01 October 1994

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

1 reference

based on heuristic

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author name string

B Evert

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

E U Griese

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

M Eichelbaum

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

publication date

1 October 1994

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

350

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

434-439

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

https://scigraph.springernature.com/pub.10.1007/bf00178963

0 references

Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/7845481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00178963

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7845481%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

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