(Q72716922)

English

The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925

scientific article published on 01 May 1993

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scholarly article

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Europe PubMed Central

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28 October 2019

The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925 (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8285144%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

author name string

B B Hasinoff

1

1 reference

Europe PubMed Central

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28 October 2019

S V Kala

2

1 reference

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28 October 2019

publication date

1 May 1993

1 reference

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28 October 2019

Agents and Actions

1 reference

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28 October 2019

39

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28 October 2019

1-2

1 reference

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28 October 2019

72-81

1 reference

Europe PubMed Central

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28 October 2019

The hydrolysis activation of the doxorubicin cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] unusually reactive for an imide?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of ferritin-bound iron to adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardioxane--ICRF-187 towards anticancer drug specificity through selective toxicity reduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADH oxidation in submitochondrial particles protects respiratory chain activity against damage by adriamycin‐Fe3+

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of iron from ferritin by cardiotoxic anthracycline antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron mobilization from ferritin using alpha-oxohydroxy heteroaromatic chelators

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships between the copper atoms of caeruloplasmin. II. An interaction between the copper binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metal binding by pharmaceuticals. Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumour agent ICRF 159 and its inactive homologue ICRF 192

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferritin iron mobilisation by chelating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Reaction of Ferric Salts with Transferrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular iron uptake from transferrin: is endocytosis the only mechanism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An unexpected hydrolysis pH-rate profile, at pH values less than 7, of the labile imide, ICRF-187: (+)-1,2-bis-(3,5-dioxopiperazin-1-yl)propane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferritin as a source of iron for oxidative damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of ICRF-187 using a daily for 3 days schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

dl-N,N'-dicarboxamidomethyl-N,N'-dicarboxymethyl-1,2-diaminopropane (ICRF-198) and d-1,2-bis(3,5-dioxopiperazine-1-yl)propane (ICRF-187) inhibition of Fe3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adria

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of the cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yL)propane); its hydrolysis product (ICRF-198); and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of transferrin-iron by adriamycin at acidic pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetics and mechanism of iron (3) exchange between chelates and transferrin. II. The presentation and removal with ethylenediaminetetraacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of iron from ferritin and its role in oxygen radical toxicities

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enzymatic hydrolysis-activation of the adriamycin cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effectiveness of (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mobilization of iron from ferritin by chelating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorative effects of ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] on the cardiotoxicity induced by doxorubicin or by isoproterenol in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reduction and release of iron from Fe3+ .transferrin.CO3(2-)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment with ICRF-187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron mobilization from ferritin by chelating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8285144

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01975717

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8285144%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8285144%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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