(Q72769183)

English

Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity

scientific article published on 01 February 1994

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

immune function

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

author name string

C Scheid

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

R Young

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

R McDermott

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

L Fitzsimmons

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

J H Scarffe

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

publication date

1 February 1994

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

Cancer Immunology, Immunotherapy

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

38

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

119-126

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

https://scigraph.springernature.com/pub.10.1007/bf01526207

0 references

The in vivo anti-tumor effect of human recombinant interleukin-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal regulation of complement biosynthesis in human cell lines--II. Upregulation of the biosynthesis of complement components C3, factor B and C1 inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of interleukin-6-enhanced lymphokine-activated killer cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of CR3, CD11b/CD18 to cytolysis by human NK cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference of a C3-fragment preparation with IL 2-dependent proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections – a phase I dose toxicity trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2-activated human killer lymphocytes but not their secreted products mediate increase in albumin flux across cultured endothelial monolayers. Implications for vascular leak syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interplay in vitro between ACTH, beta-endorphin, and glucocorticoids in the modulation of spontaneous and lymphokine-inducible human natural killer (NK) cell activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 does not support interleukin-2 induced generation of human lymphokine-activated killer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6 is a differentiation factor for human megakaryocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement activation in cancer patients undergoing immunotherapy with interleukin-2 (IL-2): binding of complement and C-reactive protein by IL-2-activated lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines Stimulate the CRH but Not the Vasopressin Neuronal System: Evidence for a Median Eminence Site of Interleukin-6 Action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of interleukin-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of leukocytic cell adhesion molecules (CD11a-c/CD18) in the enhanced NK lysis of iC3b-opsonized targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement C3: A molecular mosaic of binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 (IL-6) and acute phase proteins in the disease course of patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement deficiency and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphokine-activated killer (LAK) cells: interferon-gamma synergizes with interleukin-2 to induce LAK cytotoxicity in homogeneous leukemic preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of in vitro natural killer activity by the third component of complement: role for the C3a fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 bolus therapy induces immediate and selective disappearance from peripheral blood of all lymphocyte subpopulations displaying natural killer activity: role of cell adhesion to endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines, acute phase proteins, and tissue injury. C-reactive protein opsonizes dead cells for debridement and stimulates cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement activation by C-reactive protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentration of IL-6 in systemic lupus erythematosus; an indicator of disease activity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological and clinical aspects of interleukin 6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level expression of a bioengineered, cysteine-free hepatocyte-stimulating factor (interleukin 6)-like protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and the acute phase response

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha and interleukin 6 synergistically induce T cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-beta 2/IL-6 augments the activity of human natural killer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 augments Fc IgE receptor (Fc epsilon RII/CD23) expression on human monoblastic/monocytic cell lines U937, THP-1, and Mono-Mac-6 but not on blood monocytes. Regulatory effects of IL-4 and IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 enhances the induction of human lymphokine-activated killer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the adrenals in the acute phase response to interleukin-1 and tumor necrosis factor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human interleukin-4 (rhu IL-4) administered by the intravenous and subcutaneous routes in patients with advanced cancer--a phase I toxicity study and pharmacokinetic analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulation of the Induction Phase of Lymphokine-Activated Killer Activity by Acute Phase Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple in vivo effects of interleukin-3 and interleukin-6 on murine megakaryocytopoiesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8306367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01526207

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8306367%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

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