(Q73011653)

English

Characterization and effects of methyl-2- (4-aminophenyl)-1, 2-dihydro-1-oxo-7- (2-pyridinylmethoxy)-4-(3,4, 5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (P

scientific article published on 01 November 2000

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scholarly article

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31 October 2019

Characterization and effects of methyl-2- (4-aminophenyl)-1, 2-dihydro-1-oxo-7- (2-pyridinylmethoxy)-4-(3,4, 5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (PDE5) (English)

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31 October 2019

author name string

J Kotera

1

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31 October 2019

K Fujishige

2

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31 October 2019

H Michibata

3

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31 October 2019

K Yuasa

4

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31 October 2019

A Kubo

5

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31 October 2019

Y Nakamura

6

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31 October 2019

K Omori

7

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31 October 2019

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publication date

1 November 2000

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31 October 2019

Biochemical Pharmacology

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31 October 2019

60

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31 October 2019

9

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31 October 2019

1333-1341

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31 October 2019

Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle

1 reference

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The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation

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Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

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Nitric oxide, a novel neuronal messenger

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Nitric oxide: first in a new class of neurotransmitters

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Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation.

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Guanylin: an endogenous activator of intestinal guanylate cyclase

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Effects of KRN2391, a novel vasodilator, on pancreatic exocrine secretion in anesthetized dogs.

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Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures.

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Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases

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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

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Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)

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7 January 2021

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

1 reference

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7 January 2021

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine

1 reference

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7 January 2021

Isolation of cyclic nucleotide phosphodiesterase isozymes from pig aorta

1 reference

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Isoenzymes of cyclic nucleotide phosphodiesterase in the human aorta: characterization and the effects of E4021

1 reference

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7 January 2021

Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues

1 reference

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Occurrence of the methylisobutylxanthine-stimulated cyclic GMP binding protein in various rat tissues.

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7 January 2021

Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development

1 reference

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7 January 2021

Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene

1 reference

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7 January 2021

Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase

1 reference

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Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues

1 reference

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7 January 2021

Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.

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7 January 2021

Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta

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Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression

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Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats

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7 January 2021

Purification of rod outer segment GTP-binding protein subunits and cGMP phosphodiesterase by single-step column chromatography.

1 reference

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7 January 2021

Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase

1 reference

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7 January 2021

Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle

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7 January 2021

Purification of cGMP-binding protein phosphodiesterase from rat lung

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Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1 reference

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C-Type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells

1 reference

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Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype

1 reference

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Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds

1 reference

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7 January 2021

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10.1016/S0006-2952(00)00457-3

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31 October 2019

1 reference

Europe PubMed Central

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31 October 2019

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