(Q73024302)

English

Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis

scientific article published on 01 January 1997

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

L M Winn

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

P G Wells

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

publication date

1 January 1997

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Free Radical Biology and Medicine

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

22

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

607-621

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Diphenylhydantoin teratogenicity in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Teratogenic effects of phenytoin on chick embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Teratogenicity of diphenylhydantoin in the New Zealand white rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Teratogen update: fetal hydantoin effects

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic predisposition to phenytoin-induced birth defects

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenatal prediction of risk of the fetal hydantoin syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The embryotoxicity of phenytoin: an update on possible mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: implications for embryotoxicity and teratogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical toxicology of chemical teratogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of hydrazine-stimulated proteolysis in human erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of carbonyl content in oxidatively modified proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein degradation as an index of oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The Glutathione Status of Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical-biological reactions common to teratogenesis and mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidation of DNA bases by tumor promoter-activated processes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse fetal hydantoin syndrome: effects of maternal seizures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Culture of whole rodent embryos in teratogen screening

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Whole-embryo culture and the study of mammalian embryos during organogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunochemical detection of oxidized proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo oxidative DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative metabolism of aflatoxin B1 by lipoxygenase purified from human term placenta and intrauterine conceptal tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunohistochemical demonstration of prostaglandin E-2 in preimplantation mouse embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunohistochemical localization of prostaglandin synthase in the rat uterus and embryo during the peri-implantation period

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunohistochemical localization of prostaglandin H synthase in the embryo and uterus of the mouse from ovulation through implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Macroxyproteinase (M.O.P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Temporal expression of genes encoding free radical-metabolizing enzymes is associated with higher mRNA levels during in utero development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetes and embryonic malformations. Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of intracellular glutathione in rat embryos and visceral yolk sacs and its effect on 2-nitrosofluorene-induced malformations in the whole embryo culture system.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutathione biosynthesis in the postimplantation rat conceptus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenytoin embryotoxicity: role of enzymatic bioactivation in a murine embryo culture model

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Benzo[a]pyrene dione-benzo[a]pyrene diol oxidation-reduction couples; involvement in DNA damage, cellular toxicity, and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Endogenous oxidative DNA damage, aging, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of oxy radicals in biosystems

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Repair of H2O2-induced DNA damage in bovine lens epithelial cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900340-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0891-5849(96)00340-1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9013124%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q73024302&oldid=1945050292"