(Q73035541)

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Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

scientific article published on 01 October 2000

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scholarly article

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31 October 2019

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand (English)

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31 October 2019

phase II clinical trial

1 reference

based on heuristic

inferred from title

multiple sclerosis

1 reference

based on heuristic

inferred from title

7

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31 October 2019

12

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31 October 2019

author name string

Bielekova B

1

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31 October 2019

Goodwin B

2

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31 October 2019

Richert N

3

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31 October 2019

Cortese I

4

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31 October 2019

Kondo T

5

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31 October 2019

Afshar G

6

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31 October 2019

Eaton J

8

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31 October 2019

Antel J

9

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31 October 2019

Frank JA

10

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31 October 2019

McFarland HF

11

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31 October 2019

publication date

1 October 2000

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31 October 2019

Nature Medicine

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31 October 2019

6

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31 October 2019

10

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31 October 2019

1167-1175

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31 October 2019

https://scigraph.springernature.com/pub.10.1038/80516

0 references

Immunological aspects of demyelinating diseases

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

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inferred from DOI database lookup

Neuropathology in multiple sclerosis: new concepts

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Axonal transection in the lesions of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

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Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

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MS: a CNS and systemic autoimmune disease

1 reference

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7 January 2021

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A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

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Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna.

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple sclerosis: lessons from neuropathology

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

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The T lymphocyte in experimental allergic encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell recognition as the target for immune intervention in autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical scales for multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80516

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inferred from DOI database lookup

Characterization of MRI response to treatment with interferon beta-1b: contrast-enhancing MRI lesion frequency as a primary outcome measure.

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

1 reference

https://api.crossref.org/works/10.1038%2F80516

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Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

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Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

A very high level of crossreactivity is an essential feature of the T-cell receptor

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

1 reference

https://api.crossref.org/works/10.1038%2F80516

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based on heuristic

inferred from DOI database lookup

Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype

1 reference

https://api.crossref.org/works/10.1038%2F80516

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

1 reference

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inferred from DOI database lookup

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1 reference

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inferred from DOI database lookup

Transfer of allergic encephalomyelitis in rats by means of lymph node cells

1 reference

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7 January 2021

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Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity

1 reference

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Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor

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General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids

1 reference

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Limiting dilution analysis of the cells of immune system I. The clonal basis of the immune response

1 reference

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based on heuristic

inferred from DOI database lookup

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

1 reference

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based on heuristic

inferred from DOI database lookup

Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity

1 reference

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Identifiers

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017150%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017150%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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