(Q73047075)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10508781%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

title

Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function (English)

1 reference

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31 October 2019

author name string

R Ishima

1

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31 October 2019

D I Freedberg

2

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31 October 2019

Y X Wang

3

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31 October 2019

J M Louis

4

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31 October 2019

D A Torchia

5

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31 October 2019

publication date

1 September 1999

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31 October 2019

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31 October 2019

volume

7

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31 October 2019

page(s)

1047-1055

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31 October 2019

issue

9

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Increasing survival in AIDS patients with cytomegalovirus retinitis treated with combination antiretroviral therapy including HIV protease inhibitors

31 October 2019

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7 January 2021

Resistance to HIV protease inhibitors

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7 January 2021

Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases

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7 January 2021

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas

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7 January 2021

Structural mechanisms of HIV drug resistance

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Domain flexibility in retroviral proteases: structural implications for drug resistant mutations

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7 January 2021

A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease

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7 January 2021

Domain communication in the dynamical structure of human immunodeficiency virus 1 protease

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7 January 2021

Molecular dynamics simulation of HIV-1 protease in a crystalline environment and in solution

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7 January 2021

Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics.

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7 January 2021

Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease

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7 January 2021

Two-step binding mechanism for HIV protease inhibitors

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Inhibitor binding to the Phe53Trp mutant of HIV-1 protease promotes conformational changes detectable by spectrofluorometry.

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7 January 2021

Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.

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7 January 2021

Flexibility and function in HIV-1 protease

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7 January 2021

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.

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7 January 2021

Conformational stability and catalytic activity of HIV-1 protease are both enhanced at high salt concentration

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7 January 2021

Microsecond time scale dynamics in the RXR DNA-binding domain from a combination of spin-echo and off-resonance rotating frame relaxation measurements

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7 January 2021

Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy

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7 January 2021

A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation.

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7 January 2021

Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein

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7 January 2021

Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins

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7 January 2021

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

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7 January 2021

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

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7 January 2021

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

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7 January 2021

Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance

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7 January 2021

A side chain at position 48 of the human immunodeficiency virus type-1 protease flap provides an additional specificity determinant

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7 January 2021

Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

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7 January 2021

Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit

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7 January 2021

Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine

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7 January 2021

On the role of methionine residues in the sequence-independent recognition of nonpolar protein surfaces

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7 January 2021

Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease

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7 January 2021

Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates

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7 January 2021

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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7 January 2021

Direct measurements of the dissociation-rate constant for inhibitor-enzyme complexes via the T1 rho and T2 (CPMG) methods.

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7 January 2021

Backbone dynamics of (1-71)bacterioopsin studied by two-dimensional 1H-15N NMR spectroscopy

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7 January 2021

SPIN-ECHO STUDIES OF CHEMICAL EXCHANGE. II. CLOSED FORMULAS FOR TWO SITES

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7 January 2021

Dynamics of ribonuclease H: temperature dependence of motions on multiple time scales.

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Identifiers

DOI

1 reference

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31 October 2019

1 reference