(Q73182600)

English

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

scientific article published on 01 April 1997

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scholarly article

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2 November 2019

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9083063%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

E Wong

1

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2 November 2019

C Bayly

2

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2 November 2019

H L Waterman

3

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2 November 2019

D Riendeau

4

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2 November 2019

J A Mancini

5

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2 November 2019

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publication date

1 April 1997

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2 November 2019

Journal of Biological Chemistry

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2 November 2019

272

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2 November 2019

9280-9286

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2 November 2019

14

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2 November 2019

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Human cyclooxygenase-2 cDNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.14.9280

21 January 2018

Identifiers

10.1074/JBC.272.14.9280

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9083063%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9083063%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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