(Q73413928)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Serine 380 (P14) --> glutamate mutation activates antithrombin as an inhibitor of factor Xa (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

A Futamura

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

P G Gettins

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

0 references

publication date

1 February 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

3 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

4092-4098

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Transmission of conformational change from the heparin binding site to the reactive center of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

A mechanism for heparin-induced potentiation of antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Synthesis of pppGpN typs dinucleotide derivatives: the 5′ end sequence of some RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

The anticoagulant activation of antithrombin by heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Carbohydrate isoforms of antithrombin variant N135Q with different heparin affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Lysine-heparin interactions in antithrombin. Properties of K125M and K290M,K294M,K297M variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Effect of individual carbohydrate chains of recombinant antithrombin on heparin affinity and on the generation of glycoforms differing in heparin affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

The Size and Shape of Human and Bovine Antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

How to measure and predict the molar absorption coefficient of a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Isolation of human blood coagulation alpha-factor Xa by soybean trypsin inhibitor-sepharose chromatography and its active-site titration with fluorescein mono-p-guanidinobenzoate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Deconvolution of the fluorescence emission spectrum of human antithrombin and identification of the tryptophan residues that are responsive to heparin binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Distortion of the active site of chymotrypsin complexed with a serpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.6.4092

21 January 2018

Identifiers

DOI

10.1074/JBC.275.6.4092

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10660568%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference