(Q73427503)

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Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate

scientific article published on 01 June 1997

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3 November 2019

Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate (English)

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3 November 2019

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G K Smith

1

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3 November 2019

S Banks

2

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3 November 2019

T A Blumenkopf

3

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3 November 2019

M Cory

4

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3 November 2019

J Humphreys

5

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3 November 2019

R M Laethem

6

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3 November 2019

J Miller

7

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3 November 2019

C P Moxham

8

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3 November 2019

R Mullin

9

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3 November 2019

P H Ray

10

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3 November 2019

L M Walton

11

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3 November 2019

L A Wolfe

12

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3 November 2019

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1 June 1997

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3 November 2019

Journal of Biological Chemistry

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3 November 2019

272

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3 November 2019

25

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3 November 2019

15804-15816

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3 November 2019

The First Bagshawe lecture. Towards generating cytotoxic agents at cancer sites

1 reference

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Antibody-enzyme conjugates for cancer therapy

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Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates

1 reference

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Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate

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In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate

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21 January 2018

A cytotoxic agent can be generated selectively at cancer sites

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Site-Specific Prodrug Activation by Antibody-.beta.-Lactamase Conjugates: Preclinical Investigation of the Efficacy and Toxicity of Doxorubicin Delivered by Antibody Directed Catalysis

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21 January 2018

Carboxypeptidase-mediated release of methotrexate from methotrexate alpha-peptides

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21 January 2018

Activation of methotrexate-.alpha.-alanine by carboxypeptidase A monoclonal antibody conjugate

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A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

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21 January 2018

Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates

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21 January 2018

Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of a cytosine deaminase immunoconjugate

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21 January 2018

A phase-I study of repeated therapy with radiolabelled antibody to carcinoembryonic antigen using intermittent or continuous administration of cyclosporin A to suppress the immune response

1 reference

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21 January 2018

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

1 reference

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21 January 2018

Identification of prodrug, active drug, and metabolites in an ADEPT clinical study

1 reference

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21 January 2018

Reshaping human antibodies for therapy

1 reference

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21 January 2018

Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.

1 reference

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21 January 2018

Purification and crystallization of human carboxypeptidase A

1 reference

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21 January 2018

cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1

1 reference

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21 January 2018

The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model.

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21 January 2018

Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene

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21 January 2018

Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis

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High level expression of the humanized monoclonal antibody Campath-1H in Chinese hamster ovary cells

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Determination of the immunoreactive function of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess

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Identifiers

10.1074/JBC.272.25.15804

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9188478%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

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PubMed publication ID

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3 November 2019

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