(Q73455009)

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Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining)

scientific article published on 01 March 2000

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4 November 2019

Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining) (English)

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4 November 2019

Caroline Austin

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4 November 2019

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K Padget

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4 November 2019

R Carr

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4 November 2019

A D Pearson

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4 November 2019

M J Tilby

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4 November 2019

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1 March 2000

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4 November 2019

Biochemical Pharmacology

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4 November 2019

59

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4 November 2019

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4 November 2019

629-638

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4 November 2019

The development of combination therapy involving camptothecins: a review of preclinical and early clinical studies

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7 January 2021

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment

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7 January 2021

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

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7 January 2021

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A model for the mechanism of human topoisomerase I

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7 January 2021

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

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7 January 2021

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro

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7 January 2021

Swiveling and decatenation of replicating simian virus 40 genomes in vivo

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7 January 2021

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

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Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

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DNA topoisomerases: essential enzymes and lethal targets

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7 January 2021

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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7 January 2021

Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

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7 January 2021

The S-phase cytotoxicity of camptothecin.

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7 January 2021

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

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7 January 2021

Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis

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7 January 2021

Low-level resistance to camptothecin in a human small-cell lung cancer cell line without reduction in DNA topoisomerase I or drug-induced cleavable complex formation

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7 January 2021

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors

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7 January 2021

Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy

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7 January 2021

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

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7 January 2021

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

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7 January 2021

Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

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7 January 2021

Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy

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7 January 2021

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10.1016/S0006-2952(99)00372-X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10677579%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10677579%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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