(Q73464067)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11188692%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation (English)

1 reference

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4 November 2019

author name string

C T Farrar

1

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4 November 2019

J Ma

2

1 reference

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4 November 2019

D J Singel

3

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4 November 2019

C J Halkides

4

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4 November 2019

publication date

1 December 2000

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4 November 2019

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4 November 2019

volume

8

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4 November 2019

issue

12

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4 November 2019

page(s)

1279-1287

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Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

4 November 2019

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7 January 2021

The GTPase superfamily: conserved structure and molecular mechanism

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7 January 2021

Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate

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7 January 2021

Role of the switch II region in the conformational transition of activation of Ha-ras-p21.

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7 January 2021

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

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7 January 2021

The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin

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7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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7 January 2021

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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7 January 2021

The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride

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7 January 2021

PROTEIN STRUCTURE: GAP into the Breach

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7 January 2021

The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets

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7 January 2021

Probing the structure and mechanism of Ras protein with an expanded genetic code

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7 January 2021

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

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7 January 2021

Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling: comparisons between GDP and GTP forms

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7 January 2021

The frozen solution structure of p21 ras determined by ESEEM spectroscopy reveals weak coordination of Thr35 to the active site metal ion

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7 January 2021

The effects of cryoprotection on the structure and activity of p21 ras: implications for electron spin-echo envelope modulation spectroscopy

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7 January 2021

GTP-binding domain: three consensus sequence elements with distinct spacing

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7 January 2021

Dynamic properties of the guanine nucleotide binding protein alpha subunit and comparison of its guanosine triphosphate hydrolase domain with that of ras p21.

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7 January 2021

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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7 January 2021

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

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7 January 2021

Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change

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7 January 2021

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP

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7 January 2021

Probing the role of loop 2 in Ras function with unnatural amino acids

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7 January 2021

Ras interaction with the GTPase-activating protein (GAP).

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7 January 2021

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

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7 January 2021

Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

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7 January 2021

High frequency (139.5 GHz) electron paramagnetic resonance spectroscopy of the GTP form of p21 ras with selective 17O labeling of threonine

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7 January 2021

The effector interactions of p21ras

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7 January 2021

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis

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7 January 2021

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

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7 January 2021

X-ray structure of the magnesium(II)-pyrophosphate complex of the truncated head of Dictyostelium discoideum myosin to 2.7 A resolution

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7 January 2021

Active site comparisons highlight structural similarities between myosin and other P-loop proteins

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7 January 2021

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

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7 January 2021

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

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7 January 2021

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis

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7 January 2021

Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit

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7 January 2021

Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis.

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7 January 2021

Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.

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7 January 2021

Simulation of the solution structure of the H-ras p21-GTP complex

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7 January 2021

Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition.

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7 January 2021

An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras

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7 January 2021

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

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7 January 2021

Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR.

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7 January 2021

NMR studies of the conformational change in human N-p21ras produced by replacement of bound GDP with the GTP analog GTP gamma S

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7 January 2021

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

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7 January 2021

Conformational and dynamic differences between N-ras P21 bound to GTPgammaS and to GMPPNP as studied by NMR

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7 January 2021

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

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7 January 2021

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

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7 January 2021

The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+

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7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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7 January 2021

Active site dynamics in protein molecules: a stochastic boundary molecular-dynamics approach.

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7 January 2021

Solvent effects on protein motion and protein effects on solvent motion. Dynamics of the active site region of lysozyme

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11188692%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference