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Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription
scientific article published on 01 February 2000
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Europe PubMed Central
PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
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4 November 2019
title
Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription
(English)
1 reference
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Europe PubMed Central
PubMed publication ID
10713703
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
author
Lienhard Schmitz
series ordinal
4
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PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
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4 November 2019
author name string
Hofmann TG
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1
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Europe PubMed Central
PubMed publication ID
10713703
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4 November 2019
Hehner SP
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2
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Europe PubMed Central
PubMed publication ID
10713703
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4 November 2019
Dröge W
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3
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PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
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4 November 2019
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English
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publication date
1 February 2000
1 reference
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Europe PubMed Central
PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
published in
Oncogene
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stated in
Europe PubMed Central
PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
volume
19
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Europe PubMed Central
PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
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4 November 2019
issue
9
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Europe PubMed Central
PubMed publication ID
10713703
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4 November 2019
page(s)
1153-1163
1 reference
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Europe PubMed Central
PubMed publication ID
10713703
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1203406
0 references
cites work
Activate NF-kappa B or die?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphocyte signalling: a coordinating role for Vav?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
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7 January 2021
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inferred from DOI database lookup
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of rabaptin-5 blocks endosome fusion during apoptosis.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
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inferred from DOI database lookup
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteases to die for
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of human caspases by peptide-based and macromolecular inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential requirement for caspase 9 in apoptotic pathways in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor-alpha-induced cell killing and activation of transcription factor NF-kappaB are uncoupled in L929 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation of the IL-2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vav regulates peptide-specific apoptosis in thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspases: the proteases of the apoptotic pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and function of vav
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two CD95 (APO-1/Fas) signaling pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis signaling by death receptors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell clonal anergy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell Death in Development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspases and caspase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Complex complexes: signaling at the TCR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential ability of T cell subsets to undergo activation-induced cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functional T-cell receptor signaling pathway is required for p95vav activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203406
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1203406
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10713703
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
Dimensions Publication ID
1039023174
0 references
PubMed publication ID
10713703
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10713703
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713703%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 November 2019
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