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Staurosporine-induced neuronal death: multiple mechanisms and methodological implications
scientific article published on 01 March 2000
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Europe PubMed Central
PubMed publication ID
10745270
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
title
Staurosporine-induced neuronal death: multiple mechanisms and methodological implications
(English)
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Europe PubMed Central
PubMed publication ID
10745270
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
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Deshmukh M
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1
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Europe PubMed Central
PubMed publication ID
10745270
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
Johnson EM Jr
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2
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Europe PubMed Central
PubMed publication ID
10745270
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
publication date
1 March 2000
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Europe PubMed Central
PubMed publication ID
10745270
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retrieved
5 November 2019
published in
Cell Death & Differentiation
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Europe PubMed Central
PubMed publication ID
10745270
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
volume
7
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Europe PubMed Central
PubMed publication ID
10745270
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
issue
3
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Europe PubMed Central
PubMed publication ID
10745270
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
page(s)
250-261
1 reference
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Europe PubMed Central
PubMed publication ID
10745270
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400641
0 references
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Cell death during development of the nervous system
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell death: the significance of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ischemia-induced neuronal apoptosis
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
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Apoptosis in neurodegenerative disorders
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
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Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
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inferred from DOI database lookup
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
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inferred from DOI database lookup
Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
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The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAX is required for neuronal death after trophic factor deprivation and during development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Blocking cytochrome c activity within intact neurons inhibits apoptosis.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
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inferred from DOI database lookup
Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
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inferred from DOI database lookup
The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
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Cytochrome c: can't live with it--can't live without it.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Death substrates come alive
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of a Common Pathway of Apoptosis by Staurosporine
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Staurosporine-induced neuronal apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphological and biochemical changes in neurons: apoptosis versus mitosis
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamate-treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive expression of the machinery for programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Susceptibility to apoptosis is enhanced in immature cortical neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rapid fluorometric assay to measure neuronal survival in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
K-252 compounds: modulators of neurotrophin signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K252a in PC12 cells and normal rat chromaffin cells in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Staurosporine and K-252 compounds protect hippocampal neurons against amyloid beta-peptide toxicity and oxidative injury.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Techniques in the tissue culture of rat sympathetic neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: a phenotype indistinguishable from Bax deletion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400641
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CDD.4400641
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10745270
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed publication ID
10745270
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10745270
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10745270%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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