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p16 INK4a can initiate an autonomous senescence program
scientific article published on 01 March 2000
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
title
p16 INK4a can initiate an autonomous senescence program
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author name string
Dai CY
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Enders GH
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
language of work or name
English
0 references
publication date
1 March 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
19
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
issue
13
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
1613-1622
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1203438
0 references
cites work
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p16 gene overexpression in mouse bladder carcinomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased activity of p53 in senescing fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of p16 in human mammary epithelial cells by CpG island methylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of p16INK4a suppresses the unbounded and anchorage-independent growth of a glioblastoma cell line that lacks p16INK4a
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth suppression by p16ink4 requires functional retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of senescence in human malignant glioma cells by p16INK4A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203438
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1203438
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Dimensions Publication ID
1001521369
0 references
PubMed publication ID
10763818
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10763818
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10763818%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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