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HIV-1 entry - an expanding portal for drug discovery
scientific article published on 01 May 2000
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scholarly article
1 reference
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
title
HIV-1 entry - an expanding portal for drug discovery
(English)
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stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
main subject
drug discovery
1 reference
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inferred from title
author name string
Blair WS
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Lin PF
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2
1 reference
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
Meanwell NA
series ordinal
3
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Wallace OB
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4
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
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6 November 2019
publication date
1 May 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Drug Discovery Today
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
issue
5
1 reference
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
183-194
1 reference
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Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
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7 January 2021
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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
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Crossref
reference URL
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7 January 2021
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Primary HIV-1 resistance: a new phase in the epidemic?
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7 January 2021
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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
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HIV-1 attachment: another look.
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Crossref
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7 January 2021
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The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
HIV entry and its inhibition
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
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Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry
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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antigenic structure of the HIV gp120 envelope glycoprotein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4-gp120 interaction and AIDS pathogenesis
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and Characterization of CD4-IgG2, a Novel Heterotetramer That Neutralizes Primary HIV Type 1 Isolates
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
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The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Reduction of the viral load of HIV-1 after the intraperitoneal administration of dextrin 2-sulphate in patients with AIDS
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Crossref
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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
SPC3, a synthetic peptide derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of chemokine receptors in HIV-1 infection and pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Change in coreceptor use correlates with disease progression in HIV-1--infected individuals
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemokines and HIV-1 second receptors: the therapeutic connection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Core structure of gp41 from the HIV envelope glycoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atomic structure of the ectodomain from HIV-1 gp41
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atomic structure of a thermostable subdomain of HIV-1 gp41
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural rearrangements in the transmembrane glycoprotein after receptor binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Capture of an early fusion-active conformation of HIV-1 gp41
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the human immunodeficiency virus type 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901484-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1359-6446(00)01484-7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
10790262
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10790262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10790262%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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