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Transcriptional mechanisms in osteoblast differentiation and bone formation
scientific article published on 01 August 2003
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Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
title
Transcriptional mechanisms in osteoblast differentiation and bone formation
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
author name string
Kazuhisa Nakashima
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
Benoit de Crombrugghe
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2
1 reference
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Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
publication date
1 August 2003
1 reference
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Europe PubMed Central
PubMed ID
12902164
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Trends in Genetics
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stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
19
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
458-466
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
8
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Toward a molecular understanding of skeletal development
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Cellular interactions and signaling in cartilage development
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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
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7 January 2021
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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
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reference URL
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7 January 2021
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Leptin regulates bone formation via the sympathetic nervous system
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Heritable diseases of the skeleton. Part II: Molecular insights into skeletal development-matrix components and their homeostasis.
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Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.
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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
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7 January 2021
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Causal relationship between the loss of RUNX3 expression and gastric cancer
1 reference
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7 January 2021
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inferred from DOI database lookup
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Maturational disturbance of chondrocytes in Cbfa1-deficient mice
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Core-binding factor beta interacts with Runx2 and is required for skeletal development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cbfbeta interacts with Runx2 and has a critical role in bone development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The core-binding factor beta subunit is required for bone formation and hematopoietic maturation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
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inferred from DOI database lookup
A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
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Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
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Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.
1 reference
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Crossref
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7 January 2021
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Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
1 reference
stated in
Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1
1 reference
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Crossref
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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
1 reference
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7 January 2021
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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
1 reference
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Crossref
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7 January 2021
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Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.
1 reference
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Crossref
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7 January 2021
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The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function
1 reference
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Crossref
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The genetic transformation of bone biology
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The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
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1 reference
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7 January 2021
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1 reference
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1 reference
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1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
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1 reference
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7 January 2021
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inferred from DOI database lookup
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1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
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1 reference
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7 January 2021
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1 reference
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7 January 2021
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1 reference
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
twist is required in head mesenchyme for cranial neural tube morphogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the TWIST gene in the Saethre-Chotzen syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factor Sp3 is essential for post-natal survival and late tooth development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impaired ossification in mice lacking the transcription factor Sp3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0168-9525%2803%2900176-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0168-9525(03)00176-8
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed ID
12902164
1 reference
stated in
Europe PubMed Central
PubMed ID
12902164
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12902164%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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