(Q73783986)

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Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues

scientific article published on 01 July 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10807943%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues (English)

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6 November 2019

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J E Wright

1

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6 November 2019

C M Vaidya

2

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6 November 2019

Y Chen

3

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6 November 2019

A Rosowsky

4

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6 November 2019

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1 July 2000

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6 November 2019

Biochemical Pharmacology

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6 November 2019

60

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6 November 2019

1

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6 November 2019

41-46

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6 November 2019

Methotrexate analogs. 33. N.delta.-Acyl-N.alpha.-(4-amino-4-deoxypteroyl)-L-ornithine derivatives. Synthesis and in vitro antitumor activity

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7 January 2021

Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.

1 reference

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7 January 2021

Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).

1 reference

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7 January 2021

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow

1 reference

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7 January 2021

Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake

1 reference

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7 January 2021

Methotrexate and gamma-tert-butyl methotrexate transport in CEM and CEM/MTX human leukemic lymphoblasts

1 reference

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7 January 2021

CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.

1 reference

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7 January 2021

NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase

1 reference

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7 January 2021

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.

1 reference

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7 January 2021

A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460.

1 reference

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7 January 2021

Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

1 reference

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7 January 2021

Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells

1 reference

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7 January 2021

A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles.

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(00)00294-X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10807943%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10807943%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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