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The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C
scientific article published on 01 June 2000
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Europe PubMed Central
PubMed publication ID
10822275
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822275%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
title
The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C
(English)
1 reference
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Europe PubMed Central
PubMed publication ID
10822275
reference URL
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retrieved
6 November 2019
author name string
Z Han
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1
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Europe PubMed Central
PubMed publication ID
10822275
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6 November 2019
P Pantazis
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2
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Europe PubMed Central
PubMed publication ID
10822275
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6 November 2019
T S Lange
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3
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PubMed publication ID
10822275
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6 November 2019
J H Wyche
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4
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10822275
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E A Hendrickson
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5
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PubMed publication ID
10822275
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6 November 2019
publication date
1 June 2000
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Europe PubMed Central
PubMed publication ID
10822275
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6 November 2019
published in
Cell Death & Differentiation
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PubMed publication ID
10822275
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6 November 2019
volume
7
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10822275
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6 November 2019
issue
6
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Europe PubMed Central
PubMed publication ID
10822275
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6 November 2019
page(s)
521-530
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Europe PubMed Central
PubMed publication ID
10822275
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6 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400681
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Cell Death in Development
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Cell death throes
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7 January 2021
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Apoptotic pathways: the roads to ruin
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7 January 2021
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Cell suicide for beginners
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7 January 2021
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Human ICE/CED-3 protease nomenclature
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7 January 2021
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Proteases to die for
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Caspases: enemies within
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Death substrates come alive
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7 January 2021
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Mitochondria and apoptosis
1 reference
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Crossref
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7 January 2021
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Double identity for proteins of the Bcl-2 family
1 reference
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Crossref
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7 January 2021
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Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
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Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
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inferred from DOI database lookup
Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C: a worthwhile target for anticancer drugs?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
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Staurosporine, a potentially important gift from a microorganism.
1 reference
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reference URL
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7 January 2021
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Bisindolylmaleimide prevents cerebellar granule cells apoptosis: a possible role for PKC.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C and lipid signaling for sustained cellular responses
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase Cdelta is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
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inferred from DOI database lookup
The complexity of Raf-1 regulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear changes in apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
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inferred from DOI database lookup
Role of oncogenes in resistance and killing by cancer therapeutic agents.
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Cif (Cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is required for radiation-induced apoptosis in mouse thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of a Common Pathway of Apoptosis by Staurosporine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
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inferred from DOI database lookup
Ceramide activates the stress-activated protein kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
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inferred from DOI database lookup
Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
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7 January 2021
based on heuristic
inferred from DOI database lookup
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cytosolic factor is required for mitochondrial cytochrome c efflux during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4400681
retrieved
7 January 2021
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inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CDD.4400681
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10822275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
10822275
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10822275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822275%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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