(Q73821875)

English

Identification of the protein-drug adduct formed between aldehyde dehydrogenase and S-methyl-N,N-diethylthiocarbamoyl sulfoxide by on-line proteolytic digestion high performance liquid chromatography electrospray ionization mass spectrometry

scientific article published on 01 January 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825257%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Identification of the protein-drug adduct formed between aldehyde dehydrogenase and S-methyl-N,N-diethylthiocarbamoyl sulfoxide by on-line proteolytic digestion high performance liquid chromatography electrospray ionization mass spectrometry (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825257%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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based on heuristic

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high-performance liquid chromatography

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based on heuristic

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author name string

Shen ML

1

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7 November 2019

Johnson KL

2

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7 November 2019

Mays DC

3

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7 November 2019

Lipsky JJ

4

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7 November 2019

Naylor S

5

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7 November 2019

publication date

1 January 2000

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7 November 2019

Rapid Communications in Mass Spectrometry

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Europe PubMed Central

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7 November 2019

14

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7 November 2019

10

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7 November 2019

918-923

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7 November 2019

Pharmacogenetics of alcohol metabolism and alcoholism

1 reference

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Comparative subcellular distribution of aldehyde dehydrogenase in rat, mouse and rabbit liver

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21 January 2018

In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by s-methyl N, N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram

1 reference

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21 January 2018

Diethyldithiocarbamate methyl ester sulfoxide, an inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase and putative metabolite of disulfiram

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21 January 2018

In vivo pharmacodynamic studies of the disulfiram metabolite S-methyl N,N-diethylthiolcarbamate sulfoxide: inhibition of liver aldehyde dehydrogenase

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21 January 2018

S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase

1 reference

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21 January 2018

Inhibition of aldehyde dehydrogenase by disulfiram and its metabolite methyl diethylthiocarbamoyl-sulfoxide

1 reference

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21 January 2018

Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram

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21 January 2018

Inhibition of human mitochondrial aldehyde dehydrogenase by the disulfiram metabolite S-methyl-N,N-diethylthiocarbamoyl sulfoxide: structural characterization of the enzyme adduct by HPLC-tandem mass spectrometry

1 reference

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21 January 2018

Automated analytical system for the examination of protein primary structure

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21 January 2018

Enzyme-based high-performance liquid chromatography supports as probes of enzyme activity and inhibition: the immobilization of trypsin and alpha-chymotrypsin on an immobilized artificial membrane high-performance liquid chromatography support

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High-sensitivity determination of tyrosine-phosphorylated peptides by on-line enzyme reactor and electrospray ionization mass spectrometry

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Immobilized residue-specific endoproteinases for protein sequencing

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21 January 2018

High-sensitivity peptide mapping by capillary zone electrophoresis and microcolumn liquid chromatography, using immobilized trypsin for protein digestion

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Optimization of immobilized enzyme hydrolysis combined with high-performance liquid chromatography/thermospray mass spectrometry for the determination of neuropeptides

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Rapid verification of disulfide linkages in recombinant human growth hormone by tandem column tryptic mapping

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Microscale immobilized protease reactor columns for peptide mapping by liquid chromatography/mass spectral analyses

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21 January 2018

S-methyl-N,N-diethylthiocarbamate sulfoxide and S-methyl-N,N-diethylthiocarbamate sulfone, two candidates for the active metabolite of disulfiram

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Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli

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Microtiter plate-based determination of multiple concentration-inhibition relationships

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Direct monitoring of sequential enzymatic hydrolysis of peptides by thermospray mass spectrometry

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Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabolic activation of disulfiram in vivo

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Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis.

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10.1002/(SICI)1097-0231(20000530)14:10<918::AID-RCM966>3.0.CO;2-P

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825257%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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