(Q73842564)

English

Desensitisation of protease-activated receptor-1 (PAR-1) in rat astrocytes: evidence for a novel mechanism for terminating Ca2+ signalling evoked by the tethered ligand

scientific article published on 01 June 2000

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Desensitisation of protease-activated receptor-1 (PAR-1) in rat astrocytes: evidence for a novel mechanism for terminating Ca2+ signalling evoked by the tethered ligand (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

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inferred from title

Marina Sergeeva

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

J J Ubl

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

G Reiser

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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publication date

1 June 2000

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Journal of Physiology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

525 Pt 2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

319-330

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10835036%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Primary glial cultures as a model for studying hormone action

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin G and thrombin: evidence for two different platelet receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease-activated receptor 3 is a second thrombin receptor in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of thrombin-induced calcium signals in rat astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C beta regulates heterologous desensitization of thrombin receptor (PAR-1) in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of human protease-activated receptor 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of a potential proteinase activated receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of thrombin receptors on human umbilical vein endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a potent thrombin receptor ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of the two forms of GPIb functioning as receptors for alpha-thrombin and von Willebrand factor: Ca2+ responses of protease-treated human platelets activated with alpha-thrombin and the tethered ligand peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular consequences of thrombin-receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The seven-transmembrane-spanning receptors for endothelin and thrombin cause proliferation of airway smooth muscle cells and activation of the extracellular regulated kinase and c-Jun NH2-terminal kinase groups of mitogen-activated protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of a human thrombin receptor in Sf9 insect cells: evidence for an active tethered ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of mast cell tryptase with thrombin receptors and PAR-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor and G protein-mediated responses to thrombin in HEL cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization and recycling of activated thrombin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10835036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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