(Q73850558)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

0 references

Sawchuk RJ

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Yang Z

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

publication date

1 October 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

Advanced Drug Delivery Reviews

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

1-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

5-31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

AIDS dementia complex and primary HIV brain infection

7 November 2019

cites work

1 reference

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7 January 2021

Early HIV-1 infection and the AIDS dementia complex

1 reference

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7 January 2021

Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging

1 reference

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7 January 2021

Low prevalence of neurological and neuropsychological abnormalities in otherwise healthy HIV-1-infected individuals: results from the multicenter AIDS Cohort Study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Neuropsychological performance in HIV-1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The AIDS dementia complex: II. Neuropathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Neurologic manifestations of AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Survival with the acquired immunodeficiency syndrome. Experience with 5833 cases in New York City

1 reference

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7 January 2021

Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Early penetration of the blood-brain-barrier by HIV.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Early viral brain invasion in iatrogenic human immunodeficiency virus infection

1 reference

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7 January 2021

Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Treating AIDS dementia.

1 reference

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7 January 2021

Central nervous system as a sanctuary for HIV-1 infection despite treatment with zidovudine, lamivudine and indinavir

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The Blood-Brain Barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Drug transport in the central nervous system: role of carriers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The transport of sugars across the perfused choroid plexus of the sheep.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Application of microdialysis in pharmacokinetic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The entry of antiviral and antiretroviral drugs into the central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Microdialysis--theory and application

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Neural network predicted peak and trough gentamicin concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Penetration of zidovudine into the cerebrospinal fluid of patients infected with HIV

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The pharmacokinetics of zidovudine administered by continuous infusion in children

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Acquired immunodeficiency syndrome. Cerebrospinal fluid findings in patients before and during long-term oral zidovudine therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Zidovudine serum, cerebrospinal fluid, and brain concentrations following chronic administration of a new zidovudine formulation via an implantable pump in dogs [corrected]

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Modeling the enhanced uptake of zidovudine (AZT) into cerebrospinal fluid. 1. Effect of probenecid

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Microdialysis calibration using retrodialysis and zero-net flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Evaluation of a brain-targeting zidovudine chemical delivery system in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Efflux of zidovudine and 2',3'-dideoxyinosine out of the cerebrospinal fluid when administered alone and in combination to Macaca nemestrina

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Analysis of zidovudine distribution to specific regions in rabbit brain using microdialysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The effect on human immunodeficiency virus type 1 RNA levels in cerebrospinal fluid after initiation of zidovudine or didanosine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Effects of zidovudine in 30 patients with mild to end-stage AIDS dementia complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Thymidine transport in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Localization and mechanism of thymidine transport in the central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Independent blood-brain barrier transport systems for nucleic acid precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Zidovudine transport within the rabbit brain during intracerebroventricular administration and the effect of probenecid.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Brain, Blood, and Cerebrospinal Fluid Distribution of a Zidovudine Chemical Delivery System in Rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Dose-dependent brain delivery of zidovudine through the use of a zidovudine chemical delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The effect of dihydronicotinate N-substitution on the brain-targeting efficacy of a zidovudine chemical delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Improved brain delivery of AZT using a glycosyl phosphotriester prodrug.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Adamantane as a brain-directed drug carrier for poorly absorbed drug. 2. AZT derivatives conjugated with the 1-adamantane moiety.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy(or ethoxy)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs of 3'-azido-3'-deoxythymidine.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Synthesis, in vitro kinetics, and in vivo studies on protein conjugates of AZT: evaluation as a transport system to increase brain delivery.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Site-specific, sustained release of drugs to the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Zidovudine with probenecid: a warning

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Zidovudine update: 1990.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Study on didanosine concentrations in cerebrospinal fluid. Implications for the treatment and prevention of AIDS dementia complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Clinical pharmacology of 2',3'-dideoxyinosine in human immunodeficiency virus-infected children.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Tissue pharmacokinetics of 2',3'-dideoxyinosine in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of 2',3'-dideoxyadenosine in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of dideoxypurine nucleoside analogs in plasma and cerebrospinal fluid of rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Nucleoside transporter of cerebral microvessels and choroid plexus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Synthesis and pharmacokinetics of a dihydropyridine chemical delivery system for the antiimmunodeficiency virus agent dideoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Dideoxycytidine permeation and salvage by mouse leukemia cells and human erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

In vivo maternal-fetal pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in pigtailed macaques (Macaca nemestrina).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The ex vivo transfer of the anti-HIV nucleoside compound d4T in the human placenta

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Evaluation of safety and efficacy of 3TC (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection: a phase I/II study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Intrathecal immunoactivation in patients with HIV-1 infection is reduced by zidovudine but not by didanosine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Pilot study of the efficacy of atevirdine in the treatment of AIDS dementia complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

Regression of HIV encephalopathy and basal ganglia signal intensity abnormality at MR imaging in patients with AIDS after the initiation of protease inhibitor therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900017-4

7 January 2021

10.1016/S0169-409X(99)00017-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837765%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference