(Q73897094)

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Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

scientific article published on 01 April 2001

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11360187%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways (English)

1 reference

Europe PubMed Central

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7 November 2019

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B Degryse

1

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7 November 2019

S Orlando

2

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7 November 2019

M Resnati

3

1 reference

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7 November 2019

S A Rabbani

4

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7 November 2019

F Blasi

5

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7 November 2019

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1 April 2001

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7 November 2019

1 reference

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7 November 2019

20

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7 November 2019

16

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7 November 2019

2032-2043

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7 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204261

0 references

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

1 reference

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The inhibition of vascular smooth muscle cell migration by peptide and antibody antagonists of the alphavbeta3 integrin complex is reversed by activated calcium/calmodulin- dependent protein kinase II.

1 reference

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uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?

1 reference

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7 January 2021

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Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

1 reference

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The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors

1 reference

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Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis

1 reference

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Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1 reference

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Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA

1 reference

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7 January 2021

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Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix

1 reference

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7 January 2021

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alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

1 reference

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7 January 2021

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Selective localization of receptors for urokinase amino-terminal fragment at substratum contact sites of an in vitro-established line of human epidermal cells

1 reference

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7 January 2021

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Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1 reference

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7 January 2021

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Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells

1 reference

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7 January 2021

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A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

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Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells.

1 reference

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7 January 2021

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Insulin, growth factors, and cAMP: antagonism in the signal transduction pathways

1 reference

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7 January 2021

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Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils

1 reference

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7 January 2021

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Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model

1 reference

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7 January 2021

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Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Cell-surface acceleration of urokinase-catalyzed receptor cleavage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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The urokinase receptor is a major vitronectin-binding protein on endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

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Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

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Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

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Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

1 reference

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7 January 2021

based on heuristic

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Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

1 reference

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7 January 2021

based on heuristic

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Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor

1 reference

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Role of vitronectin and its receptors in haemostasis and vascular remodeling

1 reference

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7 January 2021

based on heuristic

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Growth factor activation of MAP kinase requires cell adhesion.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Bidirectional signaling between the cytoskeleton and integrins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin

1 reference

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7 January 2021

based on heuristic

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Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

1 reference

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7 January 2021

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Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration.

1 reference

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7 January 2021

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Melanoma cell migration on vitronectin: regulation by components of the plasminogen activation system

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of integrin function by the urokinase receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204261

7 January 2021

based on heuristic

inferred from DOI database lookup

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