(Q73940041)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

title

Dichloroacetate as metabolic therapy for myocardial ischemia and failure (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

R M Bersin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

P W Stacpoole

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

language of work or name

English

0 references

publication date

1 November 1997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

published in

American Heart Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

volume

134

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

issue

5 Pt 1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

page(s)

841-855

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.

8 November 2019

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Should the failing heart be stimulated?

7 January 2021

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Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans

7 January 2021

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Regulation of the oxidative phosphorylation rate in the intact cell

7 January 2021

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Mechanism of fatty acid effect on myocardial oxygen consumption. A phosphorus NMR study

7 January 2021

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Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation

7 January 2021

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7 January 2021

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Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart

7 January 2021

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Glycolysis preferentially inhibits ATP-sensitive K+ channels in isolated guinea pig cardiac myocytes

7 January 2021

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Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts

7 January 2021

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Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias

7 January 2021

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Lactic acidosis and other mitochondrial disorders

7 January 2021

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Early afterdepolarizations and triggered activity in rabbit cardiac Purkinje fibers recovering from ischemic-like conditions. Role of acidosis.

7 January 2021

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Total-body and myocardial substrate oxidation in congestive heart failure.

7 January 2021

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Alteration of the cytosolic-mitochondrial distribution of high-energy phosphates during global myocardial ischemia may contribute to early contractile failure

7 January 2021

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Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia

7 January 2021

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The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia

7 January 2021

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Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction. Relation to myocardial ischemia and infarct size

7 January 2021

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Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs

7 January 2021

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Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine

7 January 2021

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Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine

7 January 2021

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Regulation of lipolysis in cardiac muscle: a system similar to the hormone-sensitive lipase of adipose tissue.

7 January 2021

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Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts.

7 January 2021

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Fatty acid metabolism and contractile function in the reperfused myocardium. Multinuclear NMR studies of isolated rabbit hearts

7 January 2021

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Double-blind efficacy and safety study of a novel anti-ischemic agent, ranolazine, versus placebo in patients with chronic stable angina pectoris. Ranolazine Study Group

7 January 2021

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Effect of inhibition of lipolysis on myocardial oxygen consumption in the presence of isoproterenol

7 January 2021

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The pharmacology of dichloroacetate

7 January 2021

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7 January 2021

1 reference

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Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

7 January 2021

1 reference

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Studies on the regulation of leucine catabolism. III. Effects of dichloroacetate and 2-chloropropionate on leucine oxidation by the heart

7 January 2021

1 reference

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Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria

7 January 2021

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Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate.

7 January 2021

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Effects of dichloroacetate on the mechanical function of the isolated ischemic heart

7 January 2021

1 reference

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Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats

7 January 2021

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The effect of dichloroacetate on the isolated no flow arrested rat heart

7 January 2021

1 reference

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Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo

7 January 2021

1 reference

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Effects of dichloroacetate on myocardial substrate extraction, epicardial ST-segment elevation, and ventricular blood flow following coronary occlusion in dogs

7 January 2021

1 reference

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Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue.

7 January 2021

1 reference

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Competition between fatty acids and carbohydrate or ketone bodies as metabolic fuels for the isolated perfused heart

7 January 2021

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Diisopropylammonium dichloroaccetate: regulation of metabolic intermediates in muscle of alloxan diabetic rats

7 January 2021

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Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts

7 January 2021

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Effects of changes of pH on the contractile function of cardiac muscle

7 January 2021

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Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia. Phosphorus-31 nuclear magnetic resonance studies of porcine myocardium in vivo

7 January 2021

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A relationship between adenosine triphosphate, glycolysis and ischaemic contracture in the isolated rat heart

7 January 2021

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Glucose requirement for postischemic recovery of perfused working heart

7 January 2021

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Mechanisms of glycolytic inhibition in ischemic rat hearts

7 January 2021

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Myocardial ischemia (first of three parts).

7 January 2021

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Myocardial ischemia (second of three parts).

7 January 2021

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Myocardial ischemia (third of three parts).

7 January 2021

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Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange

7 January 2021

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The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.

7 January 2021

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Relationships between pre-ischemic ATP and glycogen content and post-ischemic recovery of rat heart.

7 January 2021

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Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment.

7 January 2021

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A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

7 January 2021

1 reference

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Effects of dichloroacetate and bicarbonate on haemodynamic parameters in healthy volunteers

7 January 2021

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Treatment of lactic acidosis with dichloroacetate

7 January 2021

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Dichloroacetate in the treatment of lactic acidosis.

7 January 2021

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Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease

7 January 2021

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Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate

7 January 2021

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Decreased postoperative myocardial fatty acid oxidation

7 January 2021

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The protective action of pyruvate on recovery of ischemic rat heart: comparison with other oxidizable substrates

7 January 2021

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Energy utilization and pyruvate as determinants of pyruvate dehydrogenase in norepinephrine-stimulated heart

7 January 2021

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Inhibition of palmitoylcarnitine oxidation by pyruvate in rat heart mitochondria

7 January 2021

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Nonenzymatic decarboxylation of pyruvate

7 January 2021

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Effect of pyruvate on rat heart thiol status during ischemia and hypoxia followed by reperfusion

7 January 2021

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Glucose, insulin, potassium protection during the course of hypothermic global ischemia and reperfusion: a new proposed mechanism by the scavenging of free radicals

7 January 2021

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Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion

7 January 2021

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Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase

7 January 2021

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Enhanced myocardial protection with adenosine

7 January 2021

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Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon.

7 January 2021

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Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period.

7 January 2021

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Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow

7 January 2021

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Influence of myocardial substrate utilization on the oxygen consumption of the heart

7 January 2021

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Comparison of the Actions of Dichloroacetate and 2-Bromopalmitate in Palmitate-Perfused Rat Hearts: Effects on Carbohydrate Metabolism, Contractility and Oxygen Consumption

7 January 2021

1 reference

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Different effects of interventions suppressing free fatty acid metabolism on myocardial ischemia

7 January 2021

1 reference

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Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses

7 January 2021

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Effects of dichloroacetate on hemodynamic responses to dynamic exercise in dogs

7 January 2021

1 reference

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10.1016/S0002-8703(97)80007-5

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398096%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference