(Q73958317)

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Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

scientific article published on 01 May 2000

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8 November 2019

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates (English)

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8 November 2019

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R Kuang

1

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8 November 2019

J B Epp

2

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8 November 2019

S Ruan

3

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8 November 2019

L S Chong

4

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8 November 2019

R Venkataraman

5

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8 November 2019

J Tu

6

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8 November 2019

S He

7

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8 November 2019

T M Truong

8

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8 November 2019

W C Groutas

9

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8 November 2019

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1 May 2000

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8 November 2019

Bioorganic & Medicinal Chemistry

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8 November 2019

8

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8 November 2019

5

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8 November 2019

1005-1016

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882012%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Serine proteinases of mast cell and leukocyte granules. A league of their own.

1 reference

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The role of phagocyte proteinases and proteinase inhibitors in multiple organ failure

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7 January 2021

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Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium

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7 January 2021

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The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease

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7 January 2021

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Lesional elastase activity in psoriasis. Diagnostic and prognostic significance

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7 January 2021

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Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis

1 reference

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7 January 2021

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Cleavage of collagen type X by human synovial collagenase and neutrophil elastase.

1 reference

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7 January 2021

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Cleavage of native type I collagen by human neutrophil elastase

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7 January 2021

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Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy

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7 January 2021

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Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema

1 reference

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7 January 2021

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Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis

1 reference

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7 January 2021

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Synthetic inhibitors of elastase

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7 January 2021

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A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster

1 reference

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7 January 2021

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Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277.

1 reference

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7 January 2021

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Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor

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7 January 2021

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Protective Effect of Elastase Inhibition Against Myocardial Dysfunction and Injury Induced by Ischemia and Reperfusion in Isolated Rat Hearts

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7 January 2021

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Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900038-9

7 January 2021

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Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold

1 reference

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7 January 2021

based on heuristic

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Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900038-9

7 January 2021

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Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900038-9

7 January 2021

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Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

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7 January 2021

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Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives

1 reference

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7 January 2021

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Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase

1 reference

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7 January 2021

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On the size of the active site in proteases. I. Papain

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7 January 2021

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2,6-Disubstituted aryl carboxylic acids, leaving groups "par excellence" for benzisothiazolone inhibitors of human leukocyte elastase

1 reference

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7 January 2021

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Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives

1 reference

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7 January 2021

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Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.

1 reference

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7 January 2021

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Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

1 reference

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Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters

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The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

1 reference

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New, sensitive fluorogenic substrates for human cathepsin G based on the sequence of serpin-reactive site loops.

1 reference

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Rapid chromatographic technique for preparative separations with moderate resolution

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Identifiers

10.1016/S0968-0896(00)00038-9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882012%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882012%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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