(Q73995456)

English

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554)

scientific article published on 01 December 1997

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554) (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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E O Aboagye

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

A D Lewis

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

M Tracy

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

P Workman

4

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8 November 2019

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publication date

1 December 1997

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8 November 2019

Biochemical Pharmacology

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8 November 2019

54

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8 November 2019

11

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8 November 2019

1217-1224

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8 November 2019

The experimental development of bioreductive drugs and their role in cancer therapy.

1 reference

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Covalent binding of a fluorinated 2-nitroimidazole to EMT-6 tumors in Balb/C mice: detection by F-19 nuclear magnetic resonance at 2.35 T

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Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo

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In vitro metabolism of misonidazole

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Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro

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The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles

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Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

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Reduction of fluoromisonidazole, a new imaging agent for hypoxia

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Activation of misonidazole by rat liver microsomes and purified NADPH-cytochrome c reductase

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The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis

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7 January 2021

Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma

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7 January 2021

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

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7 January 2021

Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein

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7 January 2021

Studies on the mechanisms of thallium-mediated inhibition of hepatic mixed function oxidase activity. Correlation with inhibition of NADPH-cytochrome c (P-450) reductase

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7 January 2021

Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen

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Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

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7 January 2021

Intracellular localization of radioactively labeled misonidazole in EMT-6-tumor cells in vitro

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7 January 2021

Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice

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7 January 2021

Misonidazole and other hypoxia markers: metabolism and applications

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7 January 2021

based on heuristic

inferred from DOI database lookup

Misonidazole binding in SCCVII tumors in relation to the tumor blood supply

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0006-2952(97)00344-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416972%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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