(Q74121567)

English

TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function

scientific article published on 01 December 1997

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

R Zell

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

P Geck

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

K Werdan

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

P Boekstegers

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

publication date

1 December 1997

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Molecular and Cellular Biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

177

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

61-67

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450646%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

https://scigraph.springernature.com/pub.10.1023/a:1006896832582

0 references

Inflammatory cytokines stimulate glucose uptake and glycolysis but reduce glucose oxidation in human dermal fibroblasts in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate Carboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subchronic exposure of cardiomyocytes to low concentrations of tumor necrosis factor alpha attenuates the positive inotropic response not only to catecholamines but also to cardiac glycosides and high calcium concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional blood flow and skeletal muscle energy status in endotoxemic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian pyruvate dehydrogenase complex: structure and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructure of cultured adult myocardial cells during anoxia and reoxygenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of decreased pyruvate dehydrogenase activity by inflammatory stimuli in sepsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in skeletal muscle pO2 after administration of anti-TNF alpha-antibody in patients with severe sepsis: comparison to interleukin-6 serum levels, APACHE II, and Elebute scores

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cardiovascular response of normal humans to the administration of endotoxin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A computer-supported oxystat system maintaining steady-state O2 partial pressures and simultaneously monitoring O2 uptake in biological systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of circulating tumor necrosis factor after endotoxin administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The coronary circulation in human septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oxygen dependence of the mitochondrial respiration rate in ascites tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological reversal of abnormal glucose regulation, BCAA utilization, and muscle catabolism in sepsis by dichloroacetate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sepsis does not impair tricarboxylic acid cycle in the heart.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the pyruvate dehydrogenase multienzyme complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and culture of embryonic and neonatal heart muscle cells: modification of transport activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle partial pressure of oxygen in patients with sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen uptake/supply dependency. Effects of short-term dobutamine infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contractile Dysfunction of “Reperfused” Neonatal Rat Heart Cells: A Model for Studying “Myocardial Stunning” at the Cellular Level?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cachectin/TNF-mediated lactate production in cultured myocytes is linked to activation of a futile substrate cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of oxygen and volume restriction in cultured cardiac cells. II. The glucose effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of oxygen delivery and mixed venous oxygenation to lactic acidosis in patients with sepsis and acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pyruvate metabolism in mammalian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of lactic acid and energy metabolism in vascular smooth muscle: effect of dichloroacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9450646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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