(Q74233348)

English

Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence

scientific article published on 01 August 2000

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10962093%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence (English)

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Europe PubMed Central

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9 November 2019

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E J Wang

1

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9 November 2019

C N Casciano

2

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9 November 2019

R P Clement

3

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9 November 2019

W W Johnson

4

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9 November 2019

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publication date

1 August 2000

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9 November 2019

number of pages

12

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Biochimica et Biophysica Acta

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Europe PubMed Central

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9 November 2019

1481

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9 November 2019

1

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9 November 2019

63-74

1 reference

Europe PubMed Central

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9 November 2019

Multiple-drug resistance in human cancer

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P-glycoprotein and multidrug resistance

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Reconstitution of Drug Transport by Purified P-glycoprotein

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Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

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Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

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Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein.

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7 January 2021

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Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis

1 reference

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7 January 2021

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Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

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Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

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Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

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7 January 2021

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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

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7 January 2021

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Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

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Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

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7 January 2021

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The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

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7 January 2021

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Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model

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7 January 2021

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Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

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7 January 2021

based on heuristic

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Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2800%2900125-4

7 January 2021

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

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7 January 2021

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Dissection of drug-binding-induced conformational changes in P-glycoprotein.

1 reference

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7 January 2021

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Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

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7 January 2021

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

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7 January 2021

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A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

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7 January 2021

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ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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Hoechst 33342 dye uptake as a probe of membrane permeability changes in mammalian cells

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P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

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Identifiers

10.1016/S0167-4838(00)00125-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10962093%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10962093%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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