Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q74238827)
Watch
English
The differential cytotoxicity of methotrexate in rat hepatocyte monolayer and spheroid cultures
scientific article published on 01 October 2000
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
The differential cytotoxicity of methotrexate in rat hepatocyte monolayer and spheroid cultures
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
main subject
cytotoxicity
0 references
methotrexate
1 reference
based on heuristic
inferred from title
author name string
T M Walker
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
P C Rhodes
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
C Westmoreland
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
publication date
1 October 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
published in
Toxicology in Vitro
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
14
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
475-485
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
cites work
Preservation and inducibility of xenobiotic metabolism in long-term cultures of adult rat liver cell aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Methotrexate hepatotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Progressive maturation resistance to microcystin-LR cytotoxicity in two different hepatospheroidal models.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An in vitro approach to the evaluation of repeat exposure in the prediction of toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatotoxicity in Wistar rats following chronic methotrexate administration: a model of human reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat hepatocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The use of liver spheroids as an in vitro model for studying induction of the stress response as a marker of chemical toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Total and free methotrexate pharmacokinetics in rheumatoid arthritis patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies of Formation and Efflux of Methotrexate Polyglutamates with Cultured Hepatic Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Factors controlling the concentrations of methotrexate in cultured hepatic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Liver cell models in in vitro toxicology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatotoxicity in a rat model caused by orally administered methotrexate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A fluorometric method for determination of oxidized and reduced glutathione in tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Assay of picomole amounts of ATP, ADP, and AMP using the luciferase enzyme system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of depletion of cellular glutathione on methotrexate influx, efflux and retention in hepatocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The absorption of low-dose methotrexate in patients with inflammatory bowel disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxicity of allyl alcohol in primary cultures of freshly isolated and cryopreserved hepatocytes maintained on hydrated collagen gels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of hepatocyte co-cultures in the assessment of drug toxicity from chronic exposure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance of the rabbit to methotrexate: Isolation of a drug metabolite with decreased cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatocyte spheroids: prolonged hepatocyte viability for in vitro modeling of nongenotoxic carcinogenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chapter 4 Preparation of Isolated Rat Liver Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term culture of rat liver cell spheroids in hormonally defined media
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term culture of adult rat hepatocyte spheroids.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of Possible Chronic Hepatotoxicity From Methotrexate for Psoriasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of organ-specific structures and functions in long-term cultures of aggregates from adult rat liver cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0887-2333%2800%2900036-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0887-2333(00)00036-9
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed publication ID
10963964
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10963964
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10963964%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit