(Q74313589)

English

Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas

scientific article published on 01 January 1998

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9502102%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9502102%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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A Tanaka

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9502102%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

T Terasawa

2

1 reference

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10 November 2019

H Hagihara

3

1 reference

Europe PubMed Central

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10 November 2019

Y Sakuma

4

1 reference

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10 November 2019

N Ishibe

5

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10 November 2019

M Sawada

6

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10 November 2019

H Takasugi

7

1 reference

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10 November 2019

H Tanaka

8

1 reference

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10 November 2019

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1 January 1998

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10 November 2019

Bioorganic & Medicinal Chemistry

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10 November 2019

6

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10 November 2019

1

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10 November 2019

15-30

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10 November 2019

Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men.

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Role of acylcoenzyme A: Cholesterol o-acyltransferase in cholesterol metabolism

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Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis

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Demonstration of a direct effect on hepatic acyl CoA: cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster

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Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis

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Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: implications for drug discovery

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Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents

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ACAT inhibitors as antiatherosclerotic agents: compounds and mechanisms

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Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

1 reference

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Inhibition of acylcoenzyme A: cholesterol acyltransferase activity by PD128O42: effect on cholesterol metabolism and secretion in CaCo-2 cells

1 reference

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7 January 2021

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Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

1 reference

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7 January 2021

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Synthesis and spectroscopic studies of 4-Formyl-4'-N,N-dimethylamino-1,1'-biphenyl: The unusual red edge effect and efficient laser generation.

1 reference

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7 January 2021

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Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).

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7 January 2021

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Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat

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Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond

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7 January 2021

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Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents

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7 January 2021

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Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity

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Syntheses and pharmacological activities of novel optically active inhibitors of acyl-CoA: cholesterol O-acyltransferase: EAB-309 ((R)-N-2-(1,3-benzodioxol-4-yl)heptyl-N'-2,6-diisopropylphenylurea) and its enantiomer.

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7 January 2021

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Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents

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The role of cholesterol esterification in ovarian steroidogenesis: studies in cultured swine granulosa cells using a novel inhibitor of acyl coenzyme A: cholesterol acyltransferase

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TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters

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FCE 27677: a novel inhibitor of acyl-CoA: cholesterol acyltransferase with potent oral hypolipidemic activity

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RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability

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Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides

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Pharmacokinetics of the acyl coenzyme A:cholesterol acyl transferase inhibitor CP-105,191 in dogs--the effect of food and sesame oil on systemic exposure following oral dosing.

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Identifiers

10.1016/S0968-0896(97)10009-8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9502102%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9502102%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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