(Q74525328)

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Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease

scientific article published on 01 April 1998

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scholarly article

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11 November 2019

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Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9579383%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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author name string

D R Richardson

1

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11 November 2019

P Ponka

2

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11 November 2019

publication date

1 April 1998

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11 November 2019

Translational Research

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11 November 2019

131

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11 November 2019

4

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11 November 2019

306-315

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11 November 2019

Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators

1 reference

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7 January 2021

Continuous subcutaenous administration of deferoxamine in patients with iron overload

1 reference

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7 January 2021

Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

1 reference

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7 January 2021

Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators

1 reference

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7 January 2021

Deferiprone-associated myelotoxicity

1 reference

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7 January 2021

Long-term treatment of transfusional iron overload with the oral iron chelator deferiprone (L1): a Dutch multicenter trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Agranulocytosis, arthritis and systemic vasculitis in a patient receiving the oral iron chelator L1 (deferiprone).

1 reference

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7 January 2021

Iron-chelation therapy with oral deferiprone in patients with thalassemia major

1 reference

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7 January 2021

Oral iron chelation with deferiprone

1 reference

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7 January 2021

Mode of action of iron (III) chelators as antimalarials. IV. Potentiation of desferal action by benzoyl and isonicotinoyl hydrazone derivatives.

1 reference

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7 January 2021

In vitro antioxidant properties of the iron chelator pyridoxal isonicotinoyl hydrazone and some of its analogs

1 reference

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7 January 2021

Analogues of pyridoxal isonicotinoyl hydrazone (PIH) as potential iron chelators for the treatment of neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture

1 reference

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7 January 2021

The release of iron and transferrin from the human melanoma cell

1 reference

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7 January 2021

Lactulose, 51Cr-labelled ethylenediaminetetra-acetate, L-rhamnose and polyethyleneglycol 400 [corrected] as probe markers for assessment in vivo of human intestinal permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Intestinal permeability: functional assessment and significance

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

A study of the mechanism of action of pyridoxal isonicotinoyl hydrazone at the cellular level using reticulocytes loaded with non-heme 59Fe

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Transport of iron and other transition metals into cells as revealed by a fluorescent probe

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II).

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II) and zinc(II)

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Pyridoxal complexes as potential chelating agents for oral therapy in transfusional iron overload.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

The effects of inhibition of heme synthesis on the intracellular localization of iron in rat reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Chelator-mediated iron efflux from reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Effective Iron Chelation following Oral Administration of an Isoniazid-Pyridoxal Hydrazone

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Effectiveness of oral iron chelators assayed in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Toxicological Study of Pyridoxal Isonicotinoyl Hydrazone: Acute and Subchronic Toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1'ol]-2-methyl-3-hydroxypyridin-4-one in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Effects of chelators on iron uptake and release by the brain in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Release of iron from endosomes is an early step in the transferrin cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Partition coefficients and their uses

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Potential protection from toxicity by oral iron chelators

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990180-9

7 January 2021

Identifiers

10.1016/S0022-2143(98)90180-9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9579383%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9579383%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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