(Q74541081)

English

Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization

scientific article published on 01 October 2001

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scholarly article

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Europe PubMed Central

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11 November 2019

Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization (English)

1 reference

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11 November 2019

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T Nagata

1

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11 November 2019

T Higashi

2

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11 November 2019

T Aoshi

3

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11 November 2019

M Suzuki

4

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11 November 2019

M Uchijima

5

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11 November 2019

Y Koide

6

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11 November 2019

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1 October 2001

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11 November 2019

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11 November 2019

20

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11 November 2019

1-2

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11 November 2019

105-114

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11 November 2019

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Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.

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MHC class II-associated invariant chain peptide replacement by T cell epitopes: engineered invariant chain as a vehicle for directed and enhanced MHC class II antigen processing and presentation

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The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells

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MHC class II antigen processing: biology of invariant chain

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Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.

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DNA-based immunization by in vivo transfection of dendritic cells

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Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

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Shared idiotopes between anti-class II monoclonal antibodies and major histocompatibility complex recognition site of T cells

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Evidence for invariant chain 85-101 (CLIP) binding in the antigen binding site of MHC class II molecules

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Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L

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Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41.

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7 January 2021

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Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1 reference

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Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

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Identifiers

10.1016/S0264-410X(01)00310-3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11567753%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11567753%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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