(Q7669683)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15884

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein dimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

protein homodimerization activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

DNA-binding transcription factor activity

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

bHLH transcription factor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

protein C-terminus binding

1 reference

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

13 references

8 April 2019

Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

In silico prediction of physical protein interactions and characterization of interactome orphans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

TFIIB-class transcription factor binding

IPI

1 reference

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

protein heterodimerization activity

3 references

8 April 2019

Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

RNA polymerase II cis-regulatory region sequence-specific DNA binding

ISA

3 references

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

DNA-binding transcription factor activity

3 references

8 April 2019

Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

transcription regulator complex

cell component

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

16 July 2018

Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

16 July 2018

HEB and E2A function as SMAD/FOXH1 cofactors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

beta-catenin-TCF complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

beta-catenin-TCF7L2 complex

IPI

1 reference

8 April 2019

The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

HEB and E2A function as SMAD/FOXH1 cofactors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

protein-DNA complex assembly

1 reference

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

DNA-templated transcription, initiation

1 reference

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

transcription initiation from RNA polymerase II promoter

1 reference

8 April 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884

positive regulation of transcription by RNA polymerase II

http://purl.uniprot.org/uniprot/P15884

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15884

Identifiers

MeSH descriptor ID

D000073940

subject named as

Transcription Factor 4

0 references

MeSH tree code

D12.776.260.108.092.937

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D12.776.930.125.500.937

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13 November 2019

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2 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata