(Q77322448)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

title

Molecular modelling of steroidogenic cytochromes P450 from families CYP11, CYP17, CYP19 and CYP21 based on the CYP102 crystal structure (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

author name string

D F Lewis

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

P Lee-Robichaud

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

publication date

1 August 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

The Journal of Steroid Biochemistry and Molecular Biology

4 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

66

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

issue

4

1 reference

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4 December 2019

page(s)

217-233

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

4 December 2019

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High-resolution crystal structure of cytochrome P450cam

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7 January 2021

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 January 2021

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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7 January 2021

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

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7 January 2021

Possible steroid binding site common to adrenal cytochrome P-450scc and prostatic steroid binding protein

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7 January 2021

Substrate-binding region of cytochrome P-450SCC (P-450 XIA1). Identification and primary structure of the cholesterol binding region in cytochrome P-450SCC.

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7 January 2021

Selective chemical modification of cytochrome P-450SCC lysine residues. Identification of lysines involved in the interaction with adrenodoxin

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7 January 2021

Cytochrome P450: structure, function, and generation of reactive oxygen species

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7 January 2021

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

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7 January 2021

Selective chemical modification of Cys264 with diiodofluorescein iodacetamide as a tool to study the membrane topology of cytochrome P450scc (CYP11A1)

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7 January 2021

The cholesterol-side-chain-cleaving cytochrome P450 spin-state equilibrium. 1. Thermodynamic analysis.

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7 January 2021

The cholesterol-side-chain-cleaving cytochrome P450 spin-state equilibrium. 2. Conformational analysis

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7 January 2021

Molecular modeling of the 3-D structure of cytochrome P-450scc

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7 January 2021

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity

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7 January 2021

Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

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7 January 2021

Cytochrome b5 promotes the synthesis of delta 16-C19 steroids by homogeneous cytochrome P-450 C21 side-chain cleavage from pig testis

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7 January 2021

The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

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7 January 2021

Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications

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7 January 2021

Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.

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7 January 2021

Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.

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7 January 2021

Structure-activity relationships and binding model of novel aromatase inhibitors

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7 January 2021

Structure-activity relationships of a new family of steroidal aromatase inhibitors. 1. Synthesis and evaluation of a series of analogs related to 19-[(methylthio)methyl]androstenedione (RU54115).

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7 January 2021

Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17

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7 January 2021

Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors

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7 January 2021

Kinetic properties of aromatase mutants Pro308Phe, Asp309Asn, and Asp309Ala and their interactions with aromatase inhibitors

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7 January 2021

Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg

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7 January 2021

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7 January 2021

Structure-function studies of human aromatase

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7 January 2021

Aromatase inhibitors--mechanisms for non-steroidal inhibitors

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7 January 2021

Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens

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7 January 2021

Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase

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7 January 2021

A three-dimensional model of aromatase cytochrome P450.

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7 January 2021

A detailed molecular model for human aromatase

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7 January 2021

A molecular model for the interaction between vorozole and other non-steroidal inhibitors and human cytochrome P450 19 (P450 aromatase)

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7 January 2021

Function and membrane topology of wild-type and mutated cytochrome P-450c21

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7 January 2021

Expression and functional study of wild-type and mutant human cytochrome P450c21 in Saccharomyces cerevisiae

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7 January 2021

Mutations of P450c21 (steroid 21-hydroxylase) at Cys428, Val281, and Ser268 result in complete, partial, or no loss of enzymatic activity, respectively

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7 January 2021

Dynamic structures of adrenocortical cytochrome P-450 in proteoliposomes and microsomes: protein rotation study

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7 January 2021

Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation

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7 January 2021

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7 January 2021

Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene

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7 January 2021

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

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7 January 2021

Point mutation of Arg440 to His in cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency

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7 January 2021

10.1016/S0960-0760(98)00032-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744519%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference