(Q77512535)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

author name string

W Knecht

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

M Löffler

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

language of work or name

English

0 references

publication date

1 November 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

published in

Biochemical Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

volume

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

page(s)

1259-1264

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

6 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Leflunomide and malononitriloamides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

The development of Brequinar as an immunosuppressive drug for transplantation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Differential susceptibility of dihydroorotate dehydrogenase/oxidase to brequinar sodium (NSC 368 390) in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Kinetics of slow and tight-binding inhibitors

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

inferred from DOI database lookup

7 January 2021

based on heuristic

Butylmalonate is a transition state analogue for aminocylase I

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Leflunomide interferes with pyrimidine nucleotide biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

Malononitrilamides inhibit T- and B-cell responsiveness in different species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900145-2

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(98)00145-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802339%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference