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IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
scientific article published on 01 January 1999
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
author name string
C A Dinarello
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
publication date
1 January 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
published in
The Journal of Allergy and Clinical Immunology
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
volume
103
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
issue
1 Pt 1
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
page(s)
11-24
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
cites work
IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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inferred from DOI database lookup
Coagulation of whole blood stimulates interleukin-1 beta gene expression
1 reference
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Crossref
reference URL
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7 January 2021
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Hyperosmotic stress as a stimulant for proinflammatory cytokine production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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Interleukins in the control of osteoclast differentiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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Induction of interferon-gamma inducing factor in the adrenal cortex
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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inferred from DOI database lookup
Defective NK cell activity and Th1 response in IL-18-deficient mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 18 stimulates HIV type 1 in monocytic cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a new cytokine that induces IFN-gamma production by T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
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inferred from DOI database lookup
Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft-vs.-host disease: synergism with IL-18.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
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inferred from DOI database lookup
Purification and characterization of the human interleukin-18 receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activity of interleukin 1 alpha and interleukin 1 beta in the stimulation of the immune response in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 1 signaling occurs exclusively via the type I receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble cytokine receptors are present in normal human urine
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The human interferon alpha/beta receptor: characterization and molecular cloning
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of soluble cytokine receptors from normal human urine by ligand-affinity and immunoaffinity chromatography
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma-inducing factor on the production of interferon-gamma by natural killer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 is a signal transducer for interleukin-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18 induces activation and association of p56(lck) and MAPK in a murine TH1 clone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemokines--chemotactic cytokines that mediate inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18 activates NF-kappaB in murine T helper type 1 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18/interferon-gamma-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IFN-gamma, IGIF, and IDDM.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Systemic production of interferon-gamma inducing factor (IGIF) versus local IFN-gamma expression involved in the development of Th1 insulitis in NOD mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potential therapeutic use of antibodies directed towards HuIFN-gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Primary demyelination in transgenic mice expressing interferon-gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of anti-human interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asthma: an epidemic in the absence of infection?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inverse association between tuberculin responses and atopic disorder.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin‐18 Enhances Lipopolysaccharide‐Induced Interferon‐γ Production in Human Whole Blood Cultures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunotherapy for multiple sclerosis: from theory to practice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Examining a paradox in the pathogenesis of human pulmonary tuberculosis: immune activation and suppression/anergy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0091-6749%2899%2970518-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0091-6749(99)70518-X
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
PubMed ID
9893178
1 reference
stated in
Europe PubMed Central
PubMed ID
9893178
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
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