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The mechanism of action of T7 DNA polymerase
scientific article published on 01 December 1998
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scholarly article
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
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9 December 2019
review article
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Europe PubMed Central
title
The mechanism of action of T7 DNA polymerase
(English)
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
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9 December 2019
author
Sylvie Doublié
series ordinal
1
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Europe PubMed Central
PubMed ID
9914251
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
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9 December 2019
author name string
T Ellenberger
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2
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
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9 December 2019
publication date
1 December 1998
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Europe PubMed Central
PubMed ID
9914251
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
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9 December 2019
published in
Current Opinion in Structural Biology
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
volume
8
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
page(s)
704-712
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Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
issue
6
1 reference
stated in
Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
cites work
Function and structure relationships in DNA polymerases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
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Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of Thermus aquaticus DNA polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Taq polymerase with DNA at the polymerase active site
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
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Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution
1 reference
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Crossref
reference URL
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7 January 2021
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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
1 reference
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Crossref
reference URL
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7 January 2021
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Polymerases and the replisome: machines within machines.
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reference URL
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7 January 2021
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inferred from DOI database lookup
DNA polymerases on the move
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reference URL
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7 January 2021
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Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processivity of DNA polymerases: two mechanisms, one goal
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides
1 reference
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Crossref
reference URL
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7 January 2021
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A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain
1 reference
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Crossref
reference URL
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7 January 2021
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A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
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inferred from DOI database lookup
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism
1 reference
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Crossref
reference URL
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7 January 2021
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Mechanistic aspects of enzymatic catalysis: lessons from comparison of RNA and protein enzymes
1 reference
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Crossref
reference URL
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7 January 2021
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How do kinases transfer phosphoryl groups?
1 reference
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Crossref
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7 January 2021
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Mg(2+)-Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions
1 reference
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Crossref
reference URL
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7 January 2021
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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates
1 reference
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Crossref
reference URL
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7 January 2021
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Unambiguous determination of the stereochemistry of nucleotidyl transfer catalyzed by DNA polymerase I from Escherichia coli
1 reference
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Crossref
reference URL
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7 January 2021
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Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Enzyme-Catalyzed Phosphoryl Transfer Reactions
1 reference
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Crossref
reference URL
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7 January 2021
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Mapping the transition state for ATP hydrolysis: implications for enzymatic catalysis
1 reference
stated in
Crossref
reference URL
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7 January 2021
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An attempt to unify the structure of polymerases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of DNA polymerase I Klenow fragment bound to duplex DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Significance of the O-helix residues of Escherichia coli DNA polymerase I in DNA synthesis: dynamics of the dNTP binding pocket
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutants affecting nucleotide recognition by T7 DNA polymerase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fidelity mechanisms in DNA replication
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational coupling in DNA polymerase fidelity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical basis of DNA replication fidelity
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multi-stage proofreading in DNA replication
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity
1 reference
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https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
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The fidelity of base selection by the polymerase subunit of DNA polymerase III holoenzyme
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Reexamination of induced fit as a determinant of substrate specificity in enzymatic reactions.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
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Efficient replication between non-hydrogen-bonded nucleoside shape analogs
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3'-5' exonuclease sites of DNA polymerase I (Klenow fragment)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities
1 reference
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https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
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Amino acid changes in a unique sequence of bacteriophage T7 DNA polymerase alter the processivity of nucleotide polymerization.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
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The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-440X%2898%2980089-4
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7 January 2021
based on heuristic
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Identifiers
DOI
10.1016/S0959-440X(98)80089-4
1 reference
stated in
Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
PubMed ID
9914251
1 reference
stated in
Europe PubMed Central
PubMed ID
9914251
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9914251%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 December 2019
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