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The V(D)J recombinase efficiently cleaves and transposes signal joints
scientific article published on 01 April 2002
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
title
The V(D)J recombinase efficiently cleaves and transposes signal joints
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
author name string
Matthew B Neiditch
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Gregory S Lee
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2
1 reference
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Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Leslie E Huye
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3
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Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Vicky L Brandt
series ordinal
4
1 reference
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Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
David B Roth
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
publication date
1 April 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
published in
Molecular Cell
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
volume
9
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
page(s)
871-878
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
cites work
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Changes in thymic function with age and during the treatment of HIV infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
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7 January 2021
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inferred from DOI database lookup
Initiation of V(D)J recombination in vitro obeying the 12/23 rule
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
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inferred from DOI database lookup
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intermolecular V(D)J recombination is prohibited specifically at the joining step
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential requirements for cis and trans V(D)J cleavage: effects of substrate length
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted transposition by the V(D)J recombinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel strand exchanges in V(D)J recombination
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
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7 January 2021
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inferred from DOI database lookup
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P nucleotides in V(D)J recombination: a fine-structure analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of excised DNA intermediates associated with V(D)J recombination at the T-cell receptor delta locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
RAG transposase can capture and commit to target DNA before or after donor cleavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation and resolution of double-strand break intermediates in V(D)J rearrangement
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VDJ recombination: a transposase goes to work
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unequal access: regulating V(D)J recombination through chromatin remodeling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of broken DNA molecules associated with V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and V(D)J recombination activity of mutated RAG-1 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Definition of a core region of RAG-2 that is functional in V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accessibility control of variable region gene assembly during T-cell development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of V(D)J recombination in double-strand break repair mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900494-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(02)00494-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
PubMed publication ID
11983177
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11983177
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983177%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
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