(Q7861688)

English

tyrosine kinase 2

mammalian protein found in Homo sapiens

TYK2
non-receptor tyrosine-protein kinase TYK2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

tyrosine-protein kinase, non-receptor Jak/Tyk2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, non-receptor, TYK2, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

type 1 angiotensin receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

growth hormone receptor binding

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein binding

determination method

5 references

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein tyrosine kinase activity

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

2 references

non-membrane spanning protein tyrosine kinase activity

determination method

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

extracellular exosome

determination method

1 reference

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

biological process

cell differentiation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

regulation of type I interferon-mediated signaling pathway

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

regulation of cell population proliferation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

type I interferon signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

innate immune response

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

interleukin-12-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

interleukin-23-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

interleukin-27-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Gene Atlas image

PBB GE TYK2 205546 s at fs.png
732 × 530; 11 KB

0 references

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Tyrosine-protein kinase, non-receptor, TYK2, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Identifiers

MeSH descriptor ID

subject named as

TYK2 Kinase

0 references

D08.811.913.696.620.682.725.124.650

0 references

D12.776.476.568.124.650

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264818

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264818

ENSP00000431885

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431885

ENSP00000432320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432320

ENSP00000432728

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432728

ENSP00000433203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433203

ENSP00000434831

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434831

ENSP00000434931

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434931

ENSP00000436175

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436175

ENSP00000436826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436826

ENSP00000465291

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465291

ENSP00000466340

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466340

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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