(Q7861688)

English

Tyrosine kinase 2

mammalian protein found in Homo sapiens

TYK2
non-receptor tyrosine-protein kinase TYK2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Tyrosine-protein kinase, non-receptor Jak/Tyk2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, non-receptor, TYK2, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

type 1 angiotensin receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

growth hormone receptor binding

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein binding

determination method

5 references

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

protein tyrosine kinase activity

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

2 references

non-membrane spanning protein tyrosine kinase activity

determination method

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

extracellular exosome

determination method

1 reference

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

biological process

cell differentiation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

regulation of type I interferon-mediated signaling pathway

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

regulation of cell population proliferation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

type I interferon signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

innate immune response

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29597&geneProductId=UniProtKB:P29597

determination method

interleukin-12-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

interleukin-23-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

interleukin-27-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29597

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Gene Atlas Image

PBB GE TYK2 205546 s at fs.png
732 × 530; 11 KB

0 references

Tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Tyrosine-protein kinase, non-receptor, TYK2, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29597

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264818

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264818

ENSP00000431885

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431885

ENSP00000432320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432320

ENSP00000432728

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432728

ENSP00000433203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433203

ENSP00000434831

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434831

ENSP00000434931

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434931

ENSP00000436175

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436175

ENSP00000436826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436826

ENSP00000465291

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465291

ENSP00000466340

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466340

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q7861688&oldid=1343332259"