(Q79113502)

English

Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases

scientific article published on 01 January 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

prostate cancer

1 reference

based on heuristic

inferred from title

neovascularization

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14524530

17 March 2024

1 reference

10.1023/A:1025461507027

https://api.crossref.org/works/10.1023/A:1025461507027

17 March 2024

author name string

Zhao Zhou

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Chadwick Mullins

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Sunita Bhagat

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Mohit Trikha

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Jeffrey A. Nemeth

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14524530

17 March 2024

Michael L. Cher

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14524530

17 March 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14524530

17 March 2024

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Clinical & Experimental Metastasis

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

20

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

413-420

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14524530%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

https://scigraph.springernature.com/pub.10.1023/a:1025461507027

0 references

Requirement of vascular integrin alpha v beta 3 for angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of alpha 6 and alpha 2 very late antigen integrins in the normal, hyperplastic, and neoplastic prostate: simultaneous demonstration of cell surface receptors and their extracellular ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adhesion molecules, extracellular matrix, and proteases in prostate carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of human prostate cancer cell lines by factors present in human osteoblast-like cells but not in bone marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical manipulation of angiogenesis: pathology, side-effects, surprises, and opportunities with novel human therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin expression and usage by prostate cancer cell lines on laminin substrata.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perspectives: adhesion receptors in bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Echistatin is a potent inhibitor of bone resorption in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence of human vascular endothelium in experimental human prostate cancer bone tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrins and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin function in osteoclasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Should bisphosphonates be the treatment of choice for metastatic bone disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic expression of platelet integrin alphaIIb beta3 in tumor cells from various species and histological origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of osteolytic bone destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin alpha V beta 3 expression by bone-residing breast cancer metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the alpha v beta 3 integrin in human melanoma cell invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin expression in human bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hemidesmosomal and extracellular matrix proteins by normal and malignant human prostate tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic bone disease induced by prostate cancer: rationale for the use of bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of tumor cell response to chemotherapy by the organ environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitronectin and its receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro)

1 reference

https://pubmed.ncbi.nlm.nih.gov/14524530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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