(Q79333224)

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Novel polymorphisms and the definition of promoter 'alleles' of the tumor necrosis factor and lymphotoxin alpha loci: inclusion in HLA haplotypes

scientific article published on 01 December 2003

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14647194%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Novel polymorphisms and the definition of promoter 'alleles' of the tumor necrosis factor and lymphotoxin alpha loci: inclusion in HLA haplotypes (English)

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Europe PubMed Central

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21 December 2019

author name string

Posch PE

1

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21 December 2019

Cruz I

2

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21 December 2019

Bradshaw D

3

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21 December 2019

Medhekar BA

4

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21 December 2019

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1 December 2003

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21 December 2019

Genes and Immunity

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21 December 2019

4

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21 December 2019

8

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21 December 2019

547-558

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21 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.gene.6364023

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Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

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Structure and chromosomal localization of the human lymphotoxin gene

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Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN.

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Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter

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Nucleotide diversity of the TNF gene region in an African village

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Polymorphism of the 5'-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese

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Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene

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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

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Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

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Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production

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Some disease-associated ancestral haplotypes carry a polymorphism of TNF.

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Haplotypic polymorphisms of the TNFB gene

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A new restriction fragment length polymorphism of the human TNF-B gene detected by AspHI digest

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In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading

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Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction

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Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease.

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Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

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A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha

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Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter

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Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

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A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria

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Multiple sclerosis: the frequency of allelic forms of tumor necrosis factor and lymphotoxin-alpha

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Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha

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A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis

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Linkage disequilibrium between tumor necrosis factor (TNF)-alpha-308 G/A promoter and TNF-beta NcoI polymorphisms: Association with TNF-alpha response of granulocytes to endotoxin stimulation.

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Cytokine gene polymorphism in human disease: on-line databases, supplement 2.

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Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions

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