(Q79602680)

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Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis

scientific article published on 19 January 2007

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24 December 2019

Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis (English)

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24 December 2019

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Chan T

1

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24 December 2019

Chen Z

2

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24 December 2019

Hao S

3

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24 December 2019

Xu S

4

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24 December 2019

Yuan J

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24 December 2019

Saxena A

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24 December 2019

Qureshi M

7

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24 December 2019

Zheng C

8

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24 December 2019

Xiang J

9

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24 December 2019

publication date

19 January 2007

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24 December 2019

Cancer Gene Therapy

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24 December 2019

14

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24 December 2019

4

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24 December 2019

409-420

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24 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7701025

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CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

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Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

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Immunosuppressive effects of apoptotic cells

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Induction of apoptosis reduces immunogenicity of human T-cell lines in mice.

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Apoptosis in the pathogenesis and treatment of disease

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Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells

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Identifiers

10.1038/SJ.CGT.7701025

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17235354%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17235354%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

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