(Q80695266)

English

Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals

scientific article published on 28 July 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

author name string

E T Kase

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

G H Thoresen

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

S Westerlund

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

K Højlund

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

A C Rustan

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

M Gaster

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

publication date

28 July 2007

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

50

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

2171-2180

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661008%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-007-0760-7

0 references

Liver X receptors in cardiovascular and metabolic disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nuclear receptor LXR is a glucose sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-based multiwell assays for the detection of substrate accumulation and oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis and sterol regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXR, a nuclear receptor that defines a distinct retinoid response pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cellular model system of differentiated human myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hyperglycaemia promotes lipogenesis and triacylglycerol accumulation in human skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the role of liver X receptors in lipid accumulation in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reduced insulin-mediated glucose oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin--evidence from cultured myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXRs regulate the balance between fat storage and oxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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