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Role of mitochondrial DNA in human aging
scientific article published on 01 November 2002
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scholarly article
1 reference
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Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
title
Role of mitochondrial DNA in human aging
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
author name string
Giuseppe Attardi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
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6 January 2020
publication date
1 November 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
published in
Mitochondrion
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
volume
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
page(s)
27-37
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
issue
1-2
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
cites work
Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Sequence and organization of the human mitochondrial genome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
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inferred from DOI database lookup
Animal mitochondrial DNA: an extreme example of genetic economy
1 reference
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Crossref
reference URL
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7 January 2021
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Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
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Age-dependent impairment of mitochondrial function in primate brain.
1 reference
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Crossref
reference URL
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7 January 2021
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Rapid evolution of animal mitochondrial DNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
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Hydroperoxide metabolism in mammalian organs
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Crossref
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7 January 2021
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Relaxed replication of mtDNA: A model with implications for the expression of disease
1 reference
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Crossref
reference URL
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7 January 2021
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Point mutations of the mtDNA control region in normal and neurodegenerative human brains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
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inferred from DOI database lookup
High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
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inferred from DOI database lookup
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
In situ photochemical crosslinking of HeLa cell mitochondrial DNA by a psoralen derivative reveals a protected region near the origin of replication
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Is cell aging caused by respiration-dependent injury to the mitochondrial genome?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
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5-Bromodeoxyuridine labeling of monomeric and catenated circular mitochondrial DNA in hela cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
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inferred from DOI database lookup
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aging: a theory based on free radical and radiation chemistry
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The aging process
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Time of the deepest root for polymorphism in human mitochondrial DNA.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
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MITOMAP: a human mitochondrial genome database--1998 update
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial role in cell aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondria and ageing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative damage and mitochondrial decay in aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A human dynamin-related protein controls the distribution of mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
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DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Liver mitochondrial respiratory functions decline with age
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900032-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1567-7249(02)00032-6
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
PubMed ID
16120306
1 reference
stated in
Europe PubMed Central
PubMed ID
16120306
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16120306%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
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