(Q83117322)

English

Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels

scientific article published on 06 April 2006

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scholarly article

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19 January 2020

Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels (English)

1 reference

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19 January 2020

author name string

Peter Szigligeti

1

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19 January 2020

Lisa Neumeier

2

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19 January 2020

Eugene Duke

3

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19 January 2020

Claire Chougnet

4

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19 January 2020

Koichi Takimoto

5

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19 January 2020

Susan Molleran Lee

6

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19 January 2020

Alexandra H Filipovich

7

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19 January 2020

Laura Conforti

8

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19 January 2020

publication date

6 April 2006

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19 January 2020

Journal of Physiology

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19 January 2020

573

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19 January 2020

Pt 2

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19 January 2020

357-370

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19 January 2020

The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation downregulates a potassium current in rat olfactory bulb neurons and a cloned Kv1.3 channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 gp160 decreases the K+ voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunology. Decoding calcium signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native Kv1.3 channels are upregulated by protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O2-sensitive K+ channels: role of the Kv1.2 -subunit in mediating the hypoxic response

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular mechanism of oxygen sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium signaling mechanisms in T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular properties and physiological roles of ion channels in the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine Kinase p56 Regulates Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator through Tyrosine Phosphorylation of IκBα following Hypoxia/Reoxygenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K+ channels as targets for specific immunomodulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-dependent ion channels in T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural killer-cell activity under conditions reflective of tumor micro-environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual regulation of the n type K+ channel in Jurkat T lymphocytes by protein kinases A and C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hypoxia on interleukin-2 mRNA expression by T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyr394 and Tyr505 are autophosphorylated in recombinant Lck protein-tyrosine kinase expressed in Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein modules and signalling networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p56lck plays a key role in transducing apoptotic signals in T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of the Kv1.3 potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of oxidants on n-type K+ channels in T lymphocytes and Xenopus oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/16600997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1113/JPHYSIOL.2006.109967

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16600997%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16600997%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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