(Q83174919)

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Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC

scientific article published on 01 April 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623753%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC (English)

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19 January 2020

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Yutaka Tokairin

1

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19 January 2020

Shizuko Kakinuma

2

1 reference

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19 January 2020

Masami Arai

3

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19 January 2020

Mayumi Nishimura

4

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19 January 2020

Mieko Okamoto

5

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19 January 2020

Eisaku Ito

6

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19 January 2020

Makoto Akashi

7

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19 January 2020

Yoshio Miki

8

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19 January 2020

Tatsuyuki Kawano

9

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19 January 2020

Takehisa Iwai

10

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19 January 2020

Yoshiya Shimada

11

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19 January 2020

publication date

1 April 2006

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19 January 2020

International Journal of Experimental Pathology

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19 January 2020

87

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19 January 2020

2

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19 January 2020

89-99

1 reference

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PubMed publication ID

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19 January 2020

Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet, cancer and aging in DNA mismatch repair deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mismatch repair system is required for S-phase checkpoint activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprevention in hereditary colorectal cancer syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MSH2-deficient murine lymphomas harbor insertion/deletion mutations in the transforming growth factor beta receptor type 2 gene and display low not high frequency microsatellite instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathology of hereditary nonpolyposis colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A panel of repeat markers for detection of microsatellite instability in murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of a mutL homolog in hereditary colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of DNA mismatch repair in platinum drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-ras andp53 mutations in hereditary non-polyposis colorectal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models for hereditary nonpolyposis colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability in sporadic carcinomas of the proximal colon: association with diploid DNA content, negative protein expression of p53, and distinct histomorphologic features

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of TGF-beta receptors in human colorectal cancer: implications for cancer development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2'-deoxyribose

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal tumorigenesis in Min mice is enhanced by X-irradiation in an age-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different genetic susceptibility to aberrant crypts and colon adenomas in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of DNA mismatch repair in acquired resistance to cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16623753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.0959-9673.2006.00464.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623753%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623753%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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